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Updated: Feb 5, 2026

Mass Spectrometry-Guided Genome Mining as a Tool to Uncover Novel Natural Products
Published on: March 12, 2020
Preparation of Structurally Diverse Compounds from the Natural Product Lycorine
Sarah Z Tasker1, Amanda E Cowfer1, Paul J Hergenrother1
1Department of Chemistry, Roger Adams Laboratory , University of Illinois at Urbana-Champaign , 600 South Mathews Avenue , Urbana , Illinois 61801 , United States.
Abstract:
The synthesis of a 52-member compound collection from the natural product lycorine is reported, highlighted by divergent cross-coupling and substitution strategies and an unusual ring rearrangement induced by reaction with aryne intermediates.
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