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Related Experiment Video

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A Murine Model of Group B Streptococcus Vaginal Colonization
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Oral vaccine based on a surface immunogenic protein mixed with alum promotes a decrease in Streptococcus agalactiae

D A Diaz-Dinamarca1, D A Soto2, Y Y Leyton2

  • 1Sección de Biotecnología, Instituto de Salud Pública de Chile, Chile; Millenium Institute on Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile.

Molecular Immunology
|September 12, 2018
PubMed
Summary

An oral vaccine targeting the Surface Immunogenic Protein (SIP) of Group B Streptococcus (GBS) effectively reduced bacterial colonization in mice. This novel vaccine formulation also stimulated a protective immune response, offering a new avenue for GBS vaccine development.

Keywords:
Oral vaccineStreptococcus agalactiaeSurface immunogenic proteinVaginal colonization

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Area of Science:

  • Vaccinology
  • Microbiology
  • Immunology

Background:

  • The Surface Immunogenic Protein (SIP) of Group B Streptococcus (GBS) is a promising vaccine target.
  • Previous studies indicate SIP induces protection against GBS challenge and intranasal immunization elicits similar effects.

Purpose of the Study:

  • To evaluate the immunogenicity and efficacy of an oral SIP-based vaccine formulated with alum in a mouse model.
  • To assess the vaccine's ability to reduce GBS colonization and induce a specific immune response.

Main Methods:

  • Oral immunization of mice with an alum-adjuvanted SIP-based vaccine.
  • Assessment of vaginal GBS colonization levels.
  • Measurement of SIP-specific antibodies and their opsonophagocytic activity.
  • Analysis of T-cell responses, including cytokine production (IFN-γ, TNF-α, IL-10, IL-2) and T-bet expression.

Main Results:

  • The oral SIP-based vaccine significantly reduced vaginal GBS colonization in mice.
  • Specific SIP-antibodies with opsonophagocytic activity against GBS were induced.
  • A Th1-type humoral response was observed, characterized by T-cell activation producing IFN-γ, TNF-α, IL-10, and IL-2, along with increased T-bet expression.

Conclusions:

  • An oral SIP-based vaccine formulated on alum is a viable strategy for reducing GBS colonization.
  • The vaccine elicits a robust immune response, including antibody production and Th1-type T-cell activation.
  • This oral vaccine represents a novel alternative for developing a Group B Streptococcus vaccine.