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Potential Gastroprotective Activity of Rice Bran (
Elsa Trinovita1, Fadlina Chany Saputri2, Abdul Mun'im3
1Faculty of Medicine, Universitas Palangka Raya, Palangka Raya 73111, Indonesia. elsa_trinovita@med.upr.ac.id.
Scientia Pharmaceutica
|September 13, 2018
Summary
Rice bran extract, rich in gamma-oryzanol, effectively protected rats against ethanol-induced gastric ulcers. This natural therapy significantly reduced ulcer formation and gastric acid, highlighting its gastroprotective potential.
Area of Science:
- Pharmacology and Natural Product Chemistry
- Gastroenterology and Toxicology
Background:
- Gamma-oryzanol, a key compound in rice bran oil, exhibits significant pharmacological properties.
- Ethanol-induced gastric ulcers are a common model for evaluating gastroprotective agents.
Purpose of the Study:
- To assess the gastroprotective efficacy of rice bran extract against ethanol-induced gastric ulcers in rats.
- To investigate the role of gamma-oryzanol in the observed protective effects.
Main Methods:
- Rice bran extract was prepared using ionic liquid-microwave-assisted extraction (IL-MAE) with [BMIM]BF₄.
- Rats were pretreated with varying doses of rice bran extract (100-400 mg/kg BW) or omeprazole.
- Gastric lesions, acidity, and mucus levels were measured after ethanol challenge.
Main Results:
- Oral administration of rice bran extract (400 mg/kg BW) significantly inhibited ulcer formation by 66.75%.
- The extract reduced gastric acid levels and increased gastric mucus production, similar to omeprazole.
- Gamma-oryzanol is proposed as the primary bioactive compound responsible for the gastroprotection.
Conclusions:
- Rice bran extract demonstrates significant gastroprotective effects against acute gastric ulcers.
- The findings support the use of rice bran extract as a natural, effective therapy for gastric ulcers, likely due to its gamma-oryzanol content.
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