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Updated: Feb 5, 2026
In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
TREM-1; Is It a Pivotal Target for Cardiovascular Diseases?
Kouassi T Kouassi1, Palanikumar Gunasekar2, Devendra K Agrawal3
1Department of Clinical and Translational Sciences, School of Medicine, Creighton University, Omaha, NE 68178, USA. TataKouassi@creighton.edu.
Insights
Inflammation drives cardiovascular diseases (CVDs). Triggering receptors expressed on myeloid cells-1 (TREM-1) amplifies inflammation in conditions like heart attack and atherosclerosis, offering potential therapeutic targets.
Area of Science:
- Immunology
- Cardiology
- Molecular Biology
Background:
- Cardiovascular diseases (CVDs) remain a leading cause of global mortality.
- Inflammation is increasingly recognized as a key factor in CVD pathogenesis and complications.
- Triggering receptors expressed on myeloid cells-1 (TREM-1) is implicated in amplifying inflammatory responses in various diseases.
Purpose of the Study:
- To comprehensively review and analyze the existing literature on the role of TREM-1 in cardiovascular diseases.
- To investigate TREM-1's involvement in the etiology, complications, and potential therapeutic strategies for CVDs.
- To provide insights for future research directions concerning TREM-1 in cardiovascular medicine.
Main Methods:
- Systematic review and critical analysis of relevant scientific studies.
- Examination of research investigating TREM-1's role in cardiovascular conditions.
- Synthesis of findings to understand TREM-1's impact on CVD pathogenesis and progression.
Main Results:
- TREM-1 plays a significant role in the inflammatory processes underlying acute and chronic cardiovascular conditions.
- Evidence suggests TREM-1 involvement in the pathogenesis of acute myocardial infarction (AMI) and atherosclerosis.
- The therapeutic potential of targeting the TREM-1 pathway in CVDs is highlighted, though further elucidation is needed.
Conclusions:
- TREM-1 is a crucial mediator of inflammation in cardiovascular diseases.
- Targeting the TREM-1 pathway presents a promising avenue for the diagnosis, management, and prognosis of CVDs.
- Further research is warranted to fully explore and validate TREM-1-based therapeutic strategies for cardiovascular conditions.
Abstract:
Cardiovascular diseases (CVDs) are as menacing as ever and still continue to kill adults worldwide, notwithstanding tremendous efforts to decrease their consequent mortality and morbidity. Lately, a growing body of research indicated that inflammation plays a pivotal role in the pathogenesis and complications of CVDs. A receptor of the immunoglobulin superfamily, triggering receptors expressed on myeloid cells-1 (TREM-1) was shown to induce and amplify the inflammation in both acute and chronic disease' pathogenesis and progression, which hence makes it one of the most important complication factors of CVDs. Thus, studies endeavored to investigate the role played by TREM-1 in CVDs with respect to their etiologies, complications, and possible therapeutics. We examined here, for the first time, the most relevant studies regarding TREM-1 involvement in CVDs. We critically analyzed and summarized our findings and made some suggestions for furtherance of the investigations with the aim to utilize TREM-1 and its pathways for diagnostic, management, and prognosis of CVDs. Overall, TREM-1 was found to be involved in the pathogenesis of acute and chronic cardiovascular conditions, such as acute myocardial infarction (AMI) and atherosclerosis. Although most therapeutic approaches are yet to be elucidated, our present research outcome displays a promising future to utilizing the TREM-1 pathway as a potential target for understanding and managing CVDs.
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