Critical Assessment of Optimal Timing to Initiate Post-Stroke Rehabilitation

Early rehabilitation following stroke is widely advocated to prevent complications associated with immobility and promote neuroplasticity. However, the optimal timing of rehabilitation remains unclear, as clinical evidence regarding very early mobilization is inconsistent with its biological rationale. This review examines the biological rationale for early post-stroke rehabilitation, compares outcomes associated with early versus delayed rehabilitation, and evaluates factors that influence the optimal timing of post-stroke rehabilitation. Early rehabilitation may reduce immobility-related complications, cardiovascular deconditioning, and muscle atrophy, while promoting neuroplasticity during a narrow window in early stroke recovery. However, these biological benefits do not consistently translate into improved clinical outcomes. The AVERT trial demonstrated that high-dose, very early mobilization initiated within 24 hours of stroke onset can decrease the chance of favorable functional outcomes, highlighting the role of rehabilitation intensity in addition to timing. In contrast, other studies have demonstrated that earlier mobilization may improve activities of daily living (ADLs), functional independence, and hospital length of stay. The discrepancy in these findings suggests that post-stroke rehabilitation should be individualized according to stroke type, severity, hemodynamic and neurological stability, and patient-specific functional and psychosocial factors. Further research is needed to determine the optimal timing, intensity, and frequency of rehabilitation for different stroke populations. Personalized rehabilitation interventions may help maximize functional recovery, minimize harm, and improve overall quality of life.