Effective Interventions in Restoring Mobility and Relieving Pain After Lower Limb Amputation

Lower-limb amputation is associated with substantial functional impairment, chronic pain, and reduced quality of life, posing significant challenges for long-term rehabilitation and community reintegration. Despite advances in surgical techniques and prosthetic technologies, many individuals continue to experience limitations in mobility and persistent pain after amputation. This narrative review synthesizes current evidence on the functional consequences of limb loss and the most effective strategies for restoring mobility and managing pain following lower-limb amputation. Key approaches to rehabilitation include structured physical therapy, prosthetic optimization, and multidisciplinary care models that address biomechanical and psychosocial factors, including recovery. Pharmacologic regimens, neuromodulation, mirror therapy, and emerging surgical interventions, such as targeted muscle reinnervation, have demonstrated promising outcomes in reducing phantom limb pain and improving functional control. In addition, innovations in neuroprosthetics, wearable sensors, and data-driven rehabilitation are expanding opportunities for personalized treatments and improved prosthetic integration. However, disparities in access to rehabilitation services and advanced prosthetic technologies remain significant barriers to many patients. Continued research emphasizing standardized outcome measures, long-term clinical trials, and multidisciplinary care frameworks will be essential to improving functional outcomes and quality of life for individuals living with limb loss.