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Towards feedback-controlled nanomedicines for smart, adaptive delivery
Stephen J Jones1, Annette F Taylor2, Paul A Beales1
11 School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK.
Experimental Biology and Medicine (Maywood, N.J.)
|September 13, 2018
Summary
This review explores adaptive drug release systems that use feedback control for precise pharmaceutical delivery. These "chrononanomedicines" offer advanced, environmentally responsive drug modulation for improved therapies.
Area of Science:
- Nanomedicine
- Drug Delivery Systems
- Biotechnology
Background:
- Pharmaceutical release from advanced drug delivery systems is critical.
- Current systems include controlled release (prolonged rate) and triggered release (rapid, stimulus-responsive).
- A need exists for more sophisticated drug release modulation.
Purpose of the Study:
- To highlight the potential of adaptive release systems for drug delivery.
- To explore continuous environmental communication and feedback control for nuanced release profiles.
- To inspire the development of novel
- chrononanomedicines
- .
Main Methods:
- Review of fundamental principles in nanomedicine.
- Examination of enzymatic nanoreactors for therapeutic applications.
- Analysis of feedback-controlled chemical systems.
- Case studies in chronobiology to illustrate adaptive release.
Main Results:
- Adaptive release systems offer subtle modulation of drug release profiles.
- Feedback control enables continuous environmental communication for precise delivery.
- Integration of nanomedicine, enzymatic systems, and control theory is key.
- Chronobiology provides a framework for time-dependent adaptive release.
Conclusions:
- Adaptive release systems represent a significant advancement in drug delivery.
- Feedback-controlled nanomedicines hold promise for personalized and effective therapies.
- The development of
- chrononanomedicines
- could revolutionize treatment by aligning drug release with biological rhythms.
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