An EEG investigation on nabilone, a synthetic cannabinoid, in rabbits

In this paper, the electroencephalographic (EEG) and behavioural effects of nabilone, a derivative compound from delta 9-tetrahydrocannabinol (delta 9-THC), are studied in comparison with those of delta 8-tetrahydrocannabinol (delta 8-THC) in rabbits. The results show that nabilone requires lower doses than delta 8-THC to elicit cortical spike-and-wave complexes, but higher doses to disrupt hippocampal theta rhythm. These data are discussed in connection with the clinical actions of nabilone in man.