Related Experiment Video
Updated: Feb 5, 2026
10:07
Identification of Post-translational Modifications of Plant Protein Complexes
Published on: February 22, 2014
24.6K
Identification of a Bromodomain-containing Protein 2
Dong Ju Lee1, Jung Hye Hwang2, Jeongim Ha2
1Department of Animal Resource Technology, Gyeongnam National University of Science & Technology, Jinju 52725, Korea.
Korean Journal for Food Science of Animal Resources
|September 13, 2018
Summary
A specific gene variant (c.1709G>C) in Bromodomain-containing protein 2 (BRD2) is linked to improved pork meat quality traits, including weight, color, and tenderness, in Berkshire pigs.
Area of Science:
- Animal Genetics
- Molecular Biology
- Meat Science
Background:
- Bromodomain-containing protein 2 (BRD2) is a nuclear kinase regulating gene transcription.
- Understanding genetic factors influencing meat quality is crucial for the swine industry.
Purpose of the Study:
- To investigate the expression of the BRD2 gene in porcine muscle.
- To identify associations between BRD2 gene polymorphisms and meat quality traits in Berkshire pigs.
Main Methods:
- BRD2 mRNA expression analysis in muscle tissue.
- Genotyping of the c.1709G>C polymorphism in the BRD2 gene.
- Statistical association analysis with various meat quality parameters in 384 pigs.
Main Results:
- BRD2 mRNA showed high expression in muscle tissue.
- The c.1709G>C polymorphism was significantly associated with carcass weight, meat color (a*), protein content, cooking loss, water-holding capacity, and postmortem carcass temperatures and pH.
- These associations were observed in 384 Berkshire pigs.
Conclusions:
- The c.1709G>C polymorphism in the porcine BRD2 gene is a potential genetic marker for enhancing meat quality.
- This finding could facilitate marker-assisted selection for improved pork production traits.
Related Concept Videos
01:13meta-Directing Deactivators: –NO2, –CN, –CHO, –CO2R, –COR, –CO2H
6.7K
All meta-directing substituents are deactivating groups. These substituents withdraw electrons from the aromatic ring, making the ring less reactive toward electrophilic substitution. For example, the nitration of nitrobenzene is 100,000 times slower than that of benzene because of the deactivating effect of the nitro group. The first step in an electrophilic aromatic substitution is the addition of an electrophile to form a resonance-stabilized carbocation. The energy diagrams for...
6.7K
01:202° Amines to N-Nitrosamines: Reaction with NaNO2
5.5K
Secondary amines react with nitrous acid to form N-nitrosamines, as depicted in Figure 1. Nitrous acid, a weak and unstable acid, is formed in situ from an aqueous solution of sodium nitrite and strong acids, such as hydrochloric acid or sulfuric acid, in cold conditions. In the presence of an acid, the nitrous acid gets protonated. The subsequent loss of water results in the formation of the electrophile known as nitrosonium ion.
5.5K
01:28Methods of Classification and Identification
1.2K
Bacterial identification relies on a diverse array of techniques to classify and understand microorganisms, each tailored to uncover specific characteristics. Traditional morphological approaches, while still valuable, are limited for closely related or structurally simple organisms. Modern methods integrate biochemical, serological, genetic, and advanced molecular tools to achieve greater accuracy.Morphological and Biochemical TechniquesMorphological characteristics, such as cell shape and...
1.2K
02:14SN2 Reaction: Kinetics
10.3K
Kinetic Studies and Significance
In a chemical reaction, a relationship exists between the concentration of reactants and the rate at which the reaction proceeds. The study to measure this relationship is known as the kinetics of a chemical reaction. Kinetic studies are used to deduce the rate law of a chemical reaction, which provides information about the species involved during the transition state of the rate-determining step. Thus, kinetic studies help to derive the mechanism of a...
In a chemical reaction, a relationship exists between the concentration of reactants and the rate at which the reaction proceeds. The study to measure this relationship is known as the kinetics of a chemical reaction. Kinetic studies are used to deduce the rate law of a chemical reaction, which provides information about the species involved during the transition state of the rate-determining step. Thus, kinetic studies help to derive the mechanism of a...
10.3K
02:04Protein-protein Interfaces
14.7K
Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
14.7K
02:15Protein and Protein Structure
88.1K
Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme...
A protein's shape is critical to its function. For example, an enzyme...
88.1K