Related Experiment Video

Updated: Feb 5, 2026

Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach
07:49

Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach

Published on: July 21, 2023

2.0K

Heart-brain Interactions in Heart Failure

Nadja Scherbakov1,2, Wolfram Doehner1,2,3

  • 1Centre for Stroke Research Berlin, Charité University Hospital Berlin, Germany.

Cardiac Failure Review
|September 13, 2018
PubMed

Insights

Heart failure (HF) impacts brain function, affecting symptoms and prognosis. Understanding the heart-brain interaction is crucial for managing HF and its comorbidities.

Area of Science:

  • Cardiology
  • Neurology
  • Medical Sciences

Background:

  • Heart failure (HF) is a global health concern with increasing incidence.
  • HF is associated with various conditions impacting disease progression, patient function, and healthcare costs.
  • The interplay between cardiac dysfunction and cerebral alterations significantly influences HF symptoms, comorbidities, and patient outcomes.

Purpose of the Study:

  • To provide a condensed overview of the 2018 Heart Failure Association's position paper on heart-brain interaction.
  • To elucidate the reciprocal relationship between pathological brain conditions and heart failure.
  • To discuss treatment-related interactions in the context of heart failure and brain health.

Main Methods:

  • Review and summarization of the 2018 position paper.
  • Analysis of the impact of brain conditions on HF.
  • Discussion of medical, interventional, and device-related treatment interactions.

Main Results:

  • Acute and chronic brain hypoperfusion negatively affect HF.
  • Impairment of higher cortical and brain stem functions are linked to HF progression.
  • Treatment strategies can influence the heart-brain axis in HF patients.

Conclusions:

  • The interaction between the heart and brain is a critical factor in heart failure management.
  • Addressing cerebral conditions is essential for improving HF patient prognosis and quality of life.
  • Further research into heart-brain interactions can optimize HF treatment strategies.

Keywords:
Heart failurecerebral perfusioncognitive impairmentneuro-cardiac reflexes

More Related Videos

Integration of Brain Tissue Saturation Monitoring in Cardiopulmonary Exercise Testing in Patients with Heart Failure04:20

Integration of Brain Tissue Saturation Monitoring in Cardiopulmonary Exercise Testing in Patients with Heart Failure

Published on: October 1, 2019

6.3K
Author Spotlight: Workflow for Integrating POCUS Data into EHR for Managing Heart Failure Patients03:47

Author Spotlight: Workflow for Integrating POCUS Data into EHR for Managing Heart Failure Patients

Published on: July 12, 2024

1.2K

Related Concept Videos

Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
952
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
3.8K
Heart Failure I: Introduction01:27

Heart Failure I: Introduction

Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
903
Heart Failure VI: Adjunct Therapies01:22

Heart Failure VI: Adjunct Therapies

Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
348
Heart Failure Drugs: Diuretics01:22

Heart Failure Drugs: Diuretics

Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
983
Heart Failure V: Medical Management01:30

Heart Failure V: Medical Management

Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
330