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Updated: Jun 25, 2026
09:20
Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
Published on: February 13, 2021
Valvular Heart Disease in Heart Failure with Preserved Ejection Fraction
Athena Adeli1,2, Revathy Sampath-Kumar3, Anne Wang1,2
1Division of Cardiology, Department of Medicine, Karolinska Institutet Stockholm, Sweden.
Cardiac Failure Review
|June 24, 2026
Summary
Heart failure with preserved ejection fraction (HFpEF) impacts quality of life. This review explores the link between valvular heart disease (VHD) and HFpEF, covering pathophysiology, epidemiology, and management.
Area of Science:
- Cardiology
- Cardiovascular Medicine
Background:
- Heart failure with preserved ejection fraction (HFpEF) significantly reduces functional capacity and quality of life, leading to high hospitalization and mortality rates.
- Valvular heart disease (VHD) is common in HFpEF patients, sharing risk factors like age, hypertension, diabetes, and coronary artery disease, suggesting intertwined pathogenesis.
Purpose of the Study:
- To review the complex relationship between valvular heart disease and HFpEF.
- To provide an overview of the pathophysiology, epidemiology, and management of key VHDs in the context of HFpEF.
Main Methods:
- Literature review focusing on the interplay between HFpEF and specific valvular heart conditions.
- Synthesis of current understanding regarding shared risk factors and progression pathways.
Main Results:
- VHD, including tricuspid regurgitation, mitral regurgitation, aortic stenosis, and aortic regurgitation, frequently coexists with HFpEF.
- Shared risk factors contribute to the development and progression of both HFpEF and VHD.
Conclusions:
- Understanding the relationship between VHD and HFpEF is crucial for effective patient management.
- Advances in percutaneous therapies for VHD offer new treatment avenues for patients with HFpEF.
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