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Related Experiment Video

Updated: Feb 5, 2026

Preparation and Metabolic Assay of 3-dimensional Spheroid Co-cultures of Pancreatic Cancer Cells and Fibroblasts

Preparation and Metabolic Assay of 3-dimensional Spheroid Co-cultures of Pancreatic Cancer Cells and Fibroblasts

Published on: August 23, 2017

Cancer Cell Metabolism Featuring Nrf2.

Payal Chatterjee^1,2, Mukesh Yadav¹, Namrata Chauhan¹

¹Department of Pharmaceutical Sciences, Softvision College, Indore, MP 452010, India.

Current Drug Discovery Technologies

|September 13, 2018

Summary

The transcription factor Nrf2

Keywords:

Nrf2 Reactive Oxygenation Species [ROS]Tricarboxylic Acid Cycle [TCA]cancer de novo lipogenesis glutathione glycolysis keap1 oxidative stress

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Published on: June 22, 2020

Area of Science:

Oncology and cellular metabolism research.

Background:

Nrf2's established role in cellular protection against oxidative stress is being challenged.
Emerging research suggests Nrf2 may promote cancer progression.

Purpose of the Study:

To investigate the dual role of Nrf2 in cancer.
To elucidate the link between Nrf2 modulation, cellular metabolism, and cancer cell energy demands.

Main Methods:

Review of current research and literature on Nrf2 in cancer.
Analysis of Nrf2's impact on cellular metabolic pathways.

Main Results:

Nrf2 activation or inhibition is critical for cancer cell survival and proliferation.
Nrf2 modulation redirects cellular metabolism to meet cancer's high energy requirements.
Genetic mutations in Nrf2 influence its role in cancer metabolism.

Conclusions:

The role of Nrf2 in cancer is context-dependent, requiring a "switch" to activate or inhibit.
Understanding Nrf2's metabolic role is crucial for developing targeted cancer therapies.
Parallel mutations may determine the therapeutic strategy for Nrf2 in cancer.