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Updated: Feb 5, 2026

Antifouling Self-assembled Monolayers on Microelectrodes for Patterning Biomolecules
Published on: August 25, 2009
A Cyclopropenethione-Phosphine Ligation for Rapid Biomolecule Labeling
Abstract:
Cyclopropenethiones are reported as new bioorthogonal reagents. These motifs react readily with substituted phosphines to provide thiocarbonyl adducts. In some cases, the ligations are >300-fold faster than analogous reactions with bioorthogonal cyclopropenones. Dialkyl cyclopropenethiones are also stable in aqueous buffers and can be used for biomolecule labeling in vitro and in cell lysate. The rapid reactivity and biocompatibility of cyclopropenethiones suggest that they will be useful probes for cellular studies.
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