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Related Concept Videos

Curing of Concrete01:20

Curing of Concrete

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The hydration of cement takes place within the water-filled capillary pores. However, environmental elements can disrupt this process by evaporating water from the concrete surfaces. Sealed concrete with a water-cement ratio below 0.5 experiences self-desiccation, leading to water loss. The water loss in concrete is mitigated by curing. This technique involves keeping the concrete saturated to maintain the necessary temperature and moisture conditions, to optimally fill the spaces in the cement...
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Curing Methods01:26

Curing Methods

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Concrete members with a small surface-to-volume ratio are cured by oiling and moistening the forms before casting the concrete member. These forms can be left in place for a prolonged period to prevent moisture loss, and can be wetted if made of a material suitable for wetting. If the forms are removed early, the concrete member is moistened and covered with polythene sheets to maintain moisture. For large horizontal concrete surfaces exposed to dry weather, a temporary covering is suspended...
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Accelerated Curing of Concrete01:25

Accelerated Curing of Concrete

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Accelerating concrete curing is achieved by applying heat and additional moisture. This process accelerates the hydration of the cement, resulting in an earlier strength gain in the concrete. Steam curing is a method wherein the concrete products are either transported through a chamber on a conveyor belt or encased in plastic, allowing steam at atmospheric pressure to circulate freely around them. This process begins with a phase of moist curing that typically lasts between 3 to 5 hours, after...
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Atherosclerosis III: Management01:26

Atherosclerosis III: Management

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Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
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Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

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Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
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Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

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Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
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Quantification of Atherosclerosis in Mice
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Can We Cure Atherosclerosis?

Jennifer G Robinson1, Michael H Davidson2

  • 1Departments of Epidemiology & Medicine, University of Iowa College of Public Health and Carver College of Medicine, Iowa City, IA.

Reviews in Cardiovascular Medicine
|September 13, 2018
PubMed
Summary
This summary is machine-generated.

A new trial, CURing Early ATHEROsclerosis (CURE ATHERO), proposes intensive therapy to regress atherosclerosis plaque. This approach aims for a cure, potentially reducing cardiovascular disease mortality through targeted lipoprotein lowering.

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Area of Science:

  • Cardiovascular Medicine
  • Translational Research
  • Clinical Trials

Background:

  • Cardiovascular disease mortality is increasing in the US.
  • Atherosclerosis is a significant contributor to cardiovascular disease.
  • Apolipoprotein B lipoproteins are causally linked to atherosclerosis progression.

Purpose of the Study:

  • To propose a proof-of-concept, first-in-human trial to cure atherosclerosis.
  • To investigate intensive induction and intermittent maintenance therapy for plaque regression.
  • To establish a novel treatment paradigm for early-stage atherosclerosis.

Main Methods:

  • The proposed trial, CURE ATHERO, will utilize an intensive induction therapy phase.
  • A subsequent intermittent maintenance therapy phase is planned.
  • The study focuses on achieving extensive plaque regression.

Main Results:

  • Intensive low-density lipoprotein cholesterol (LDL-C) lowering shows potential for substantial impact on early atherosclerosis.
  • Evidence supports the causal role of apolipoprotein B in atherosclerosis.
  • The proposed model aims for plaque regression, not just prevention.

Conclusions:

  • The CURE ATHERO trial offers a novel approach to potentially cure atherosclerosis.
  • Intensive induction followed by intermittent therapy may be more cost-effective and safer than lifetime treatment.
  • This strategy could significantly impact cardiovascular disease mortality rates.