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Cancer Immunotherapy: A Simple Guide for Interventional Radiologists of New Therapeutic Approaches.
A Digklia1, R Duran2,3, K Homicsko4
1Department of Oncology, CHUV, Lausanne, 1011, Switzerland. antonia.digklia@chuv.ch.
Cardiovascular and Interventional Radiology
|September 14, 2018
Summary
Cancer treatment is advancing with novel immunotherapies like immune checkpoint blockade and engineered T cells. This review explains their mechanisms and toxicities.
Area of Science:
- Oncology
- Immunology
- Cancer Therapy
Background:
- Systemic immune-targeted therapies have significantly expanded cancer treatment options.
- Novel immunotherapy approaches, including immune checkpoint blockade and engineered cytotoxic T lymphocytes, show promising clinical results.
Purpose of the Study:
- To review current cancer immunotherapy strategies.
- To explain their mechanisms of action and common toxicities.
Main Methods:
- Review of current literature on cancer immunotherapy.
- Explanation of immune checkpoint blockade and engineered T cell therapies.
- Discussion of treatment combinations with radiotherapy and ablative therapies.
Main Results:
- Immunotherapy, particularly immune checkpoint blockade and engineered T cells, offers encouraging outcomes in late-stage clinical development.
- Significant interest exists in combining these immunotherapies with other cancer treatments.
Conclusions:
- Cancer immunotherapy represents a major advancement in treatment options.
- Understanding mechanisms and toxicities is crucial for effective application and further development.
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