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Lixiang Zhai1, Zi-Wan Ning1, Tao Huang1
1School of Chinese Medicine, Hong Kong Baptist University, Kowloon, Hong Kong.
Frontiers in Pharmacology
|September 14, 2018
Summary
Cyclocarya paliurus (CP) leaf tea effectively improved lipid profiles in diabetic mice with dyslipidemia. This study identified key compounds and pathways, suggesting CP as a potential natural treatment for managing diabetic dyslipidemia.
Area of Science:
- Metabolomics and Pharmacology
- Natural Product Research
- Endocrinology and Metabolic Diseases
Background:
- Diabetic dyslipidemia, characterized by hyperlipidemia and hepatic steatosis, affects over 75% of type 2 diabetes patients.
- Cyclocarya paliurus (CP) leaf tea is traditionally used for obesity and diabetes, with prior evidence suggesting hypolipidemic effects.
- The precise mechanisms and active components of CP's lipid-lowering effects remain largely unelucidated.
Purpose of the Study:
- To investigate the beneficial effects of CP on diabetic dyslipidemia in a mouse model.
- To elucidate the underlying mechanisms of CP's action using integrated lipidomics, serum-pharmacochemistry, and network pharmacology.
- To identify active phytochemical compounds in CP responsible for its therapeutic effects.
Main Methods:
- Utilized lipidomics to analyze serum and hepatic lipid profiles in CP-treated diabetic mice.
- Employed serum-pharmacochemistry to identify CP-derived compounds in circulation.
- Applied network pharmacology to predict molecular targets and signaling pathways involved in CP's effects.
Main Results:
- CP treatment significantly improved serum and hepatic levels of total triglyceride, total cholesterol, LDL, and HDL in diabetic mice.
- CP administration led to normalization of 30 specific lipids, including cholesterol ester, diglyceride, phosphatidylethanolamine, phosphatidylcholine, and sphingomyelin.
- Identified 14 CP phytochemical compounds in mouse serum and predicted key molecular targets (e.g., ALOX12, PTPN1) and pathways (PI3K, MAPK signaling).
Conclusions:
- Cyclocarya paliurus leaf tea demonstrates significant beneficial effects on diabetic dyslipidemia by reducing hepatic lipid accumulation and regulating circulatory lipids.
- The therapeutic actions are potentially mediated through the modulation of PI3K and MAPK signaling pathways.
- This study provides a mechanistic basis for the traditional use of CP in managing metabolic disorders associated with type 2 diabetes.