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User considerations in assessing pharmacogenomic tests and their clinical support tools
Gouri Mukerjee1, Andrea Huston1, Boyko Kabakchiev1,2
1GeneYouIn Inc., 156 Front St. W., Toronto, ON Canada.
NPJ Genomic Medicine
|September 14, 2018
Summary
Pharmacogenomic (PGx) testing offers personalized medication management but varies in technology and genetic factors. Understanding these differences is key to its wider adoption and improved patient outcomes.
Area of Science:
- Pharmacogenomics
- Genetics
- Clinical Pharmacology
Background:
- Pharmacogenomic (PGx) testing is increasingly recognized for evidence-based medication management.
- Variations in PGx test technology and genetic factors affect specificity, sensitivity, and user value.
- Barriers to PGx adoption include unfamiliarity, lack of guideline knowledge, and insufficient institutional support.
Purpose of the Study:
- To demystify the PGx testing market and promote its acceptance as a standard of care.
- To highlight key factors to consider when evaluating PGx tests.
- To discuss the current progress in PGx implementation.
Main Methods:
- Review of current pharmacogenomic testing technologies.
- Analysis of genetic factors influencing test performance.
- Discussion of implementation strategies and educational needs.
Main Results:
- PGx tests differ significantly in technological specifications and genetic targets.
- Lack of standardized guidelines and institutional support hinders widespread PGx adoption.
- Addressing these factors can enhance the value and acceptance of PGx testing.
Conclusions:
- Demystifying the PGx marketplace is crucial for its integration into standard clinical practice.
- Understanding PGx test variability is essential for optimal medication management.
- Wider implementation of PGx testing promises improved drug outcomes and long-term patient value.
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