Related Experiment Video
Updated: Jul 31, 2026

08:06
Use of a Low-flow Digital Anesthesia System for Mice and Rats
Published on: September 7, 2016
COMPARISON OF PROPOFOL CONSTANT RATE INFUSION AND ISOFLURANE FOR MAINTENANCE OF ANESTHESIA IN SPEKE'S GAZELLE,
Summary
Propofol constant rate infusion (CRI) effectively maintains anesthesia in Speke
Area of Science:
- Veterinary Anesthesiology
- Wildlife Medicine
- Pharmacology
Background:
- Anesthesia protocols for Speke's gazelle (Gazella spekei) require evaluation for improved patient outcomes.
- Propofol constant rate infusion (CRI) is a potential alternative maintenance anesthetic agent.
Purpose of the Study:
- To compare propofol CRI with isoflurane for maintenance anesthesia in Speke's gazelle.
- To assess anesthetic recovery times and quality in this species.
Main Methods:
- A complete crossover study design was used with eight adult Speke's gazelle.
- Animals received either propofol CRI or isoflurane for 45 minutes following induction.
- Physiologic variables, blood gases, recovery times, and ataxia were monitored.
Main Results:
- Propofol CRI resulted in lower respiratory rates and more stable blood pressure compared to isoflurane.
- Recovery times were similar between the two anesthetic protocols.
- While propofol-treated animals had higher ataxia scores, the differences were not clinically significant.
Conclusions:
- Propofol CRI (0.4 mg/kg/min) is an effective maintenance anesthetic for Speke's gazelle.
- This protocol is suitable for noninvasive procedures requiring intubation and ventilation.
More Related Videos
08:16Optogenetic Activation of Afferent Pathways in Brain Slices and Modulation of Responses by Volatile Anesthetics
Published on: July 23, 2020
09:36Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device
Published on: September 24, 2020
Related Concept Videos
Stages of General Anesthesia
Various sedation levels offer significant advantages in facilitating procedural interventions for patients undergoing medical or invasive surgical procedures. These levels span from anxiolysis to general anesthesia, providing a spectrum of sedative effects to cater to specific patient needs. Anxiolysis reduces anxiety and is achieved through minimal sedation, enabling patients to remain awake and responsive while feeling more at ease during the procedure. This level can benefit minor...
Parenteral Anesthetics: Overview
Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
Inhalational Anesthetics: Overview
Inhalation anesthetics are drugs that induce general anesthesia upon inhalation. They work by increasing the sensitivity of GABAA receptors or inhibiting NMDA receptors, leading to a decrease in central nervous system activity. The depth of anesthesia can be rapidly adjusted by changing the concentration of the inhaled gas. Some common examples of inhalational anesthetics include volatile liquids like isoflurane, desflurane, sevoflurane and gases like xenon and nitrous oxide. Isoflurane, a...