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Updated: Feb 5, 2026
08:49
Presynaptic Dopamine Dynamics in Striatal Brain Slices with Fast-scan Cyclic Voltammetry
Published on: January 12, 2012
22.5K
Striatal dopamine and the temporal control of behavior.
Benjamin J De Corte1, Lucia M Wagner2, Matthew S Matell3
1Department of Neurology, The University of Iowa, Iowa City, IA, 52242, USA.
Behavioural Brain Research
|September 15, 2018
Summary
Dopamine receptors in the striatum influence timing behaviors. Blocking D2 receptors delayed response initiation and termination, particularly in the dorsomedial striatum, highlighting its role in temporal control.
Area of Science:
- Neuroscience
- Behavioral Science
Background:
- Striatal dopamine is crucial for temporal regulation of behavior.
- Dopamine acts via D1 and D2 receptors, but their distinct roles in timing are not fully understood.
Purpose of the Study:
- To investigate the differential roles of D1 and D2 dopamine receptors in the dorsomedial and dorsolateral striatum in temporal control of behavior.
Main Methods:
- Rats were trained on a timing task requiring decisions to initiate and terminate responses.
- The effects of blocking D1 or D2 dopamine receptors in specific striatal regions were evaluated.
Main Results:
- D2 receptor blockade in both dorsomedial and dorsolateral striatum delayed response initiation and termination, with a more pronounced effect in the dorsomedial striatum.
- D1 receptor blockade in the dorsomedial striatum delayed response termination but not initiation.
- D1 receptor blockade in the dorsolateral striatum showed no significant effects.
Conclusions:
- Striatal dopamine receptor subtypes differentially modulate temporal decision-making thresholds.
- The dorsomedial striatum plays a critical role in the neural circuitry underlying the temporal control of action.
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