A scanning electron microscopic and immunologic study of B-cell lymphosarcoma cells in cerebrospinal fluid

Homogenous populations of malignant cells from the spinal fluids of two patients with metastatic lymphosarcoma were studied immunologically and by scanning electron microscopy (SEM). The malignant cells in both spinal fluids were shown to be of B-cell origin. The surface morphology of these cells was variable with the majority of the cells having numerous microvilli and a minority having few or no microvilli. This appears to be the first report on the surface ultrastructure of B-lymphosarcoma cells suspended in spinal fluid.