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Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma
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Apatinib mesylate tablet in the treatment of advanced malignant melanoma

Lingge Yang1,2, Huiyan Zhu1,2, Peng Luo1,2

  • 1Department of Bone and Soft Tissue Sarcomas, Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China, cmwang1975@163.com.

Oncotargets and Therapy
|September 15, 2018
PubMed
Abstract

Insights

Apatinib mesylate tablets showed a 59.1% disease control rate in advanced malignant melanoma patients who failed chemotherapy. The treatment was well-tolerated, with manageable side effects.

Area of Science:

  • Oncology
  • Pharmacology
  • Clinical Trials

Background:

  • Malignant melanoma (MM) is a significant cause of cancer mortality.
  • Advanced MM often requires novel therapeutic strategies beyond conventional chemotherapy.
  • Evaluating targeted therapies like apatinib is crucial for improving patient outcomes.

Purpose of the Study:

  • To assess the clinical efficacy and safety of apatinib mesylate tablets.
  • To determine the treatment response in patients with advanced malignant melanoma.
  • To evaluate apatinib's role in patients refractory to standard treatments.

Main Methods:

  • Retrospective analysis of 22 metastatic MM patients treated with apatinib mesylate (500 mg/day).
  • Patients had previously failed conventional chemotherapy.
  • Efficacy assessed by RECIST 1.1 criteria; adverse events (AEs) graded by NCI-CTCAE 4.0.

Main Results:

  • Objective remission rate (ORR) was 9.1%, with a disease control rate (DCR) of 59.1%.
  • Median progression-free survival (PFS) was 7.5 months; 6-month PFS rate was 54.7%.
  • Adverse events were manageable and primarily Grade 1-3.

Conclusions:

  • Apatinib mesylate demonstrates a certain curative effect in advanced malignant melanoma (Stage IV) post-chemotherapy failure.
  • A daily dose of 500 mg apatinib mesylate is generally well-tolerated.
  • Apatinib offers a potential treatment option for refractory malignant melanoma cases.
Keywords:
adverse reactionapatinibefficacymalignant melanomatargeted therapy

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