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Updated: Feb 5, 2026

Using Looming Visual Stimuli to Evaluate Mouse Vision
Published on: June 13, 2019
Effects of relative negative spherical aberration in single vision contact lens visual performance
Danny Kho1, Cathleen Fedtke1,2, Daniel Tilia1,2
1Brien Holden Vision Institute, Clinical Trial Research Centre, Sydney, NSW, Australia, r.bakaraju@brienholdenvision.org.
Objective:
The study aimed to compare the visual performance of contact lenses with and without negative spherical aberration (SA) over 5 days of wear.
Methods:
At baseline, 32 myopic participants (aged 18-33 years) were fitted in a randomized order with two lenses (test lens with minimal or no SA and 1-Day Acuvue Moist designed with negative SA) for 5 days (minimum 6 hours wear/day). Participants returned for a follow-up visit. This consisted of on-axis SA measurements; high- and low-contrast visual acuities at 6 m; high-contrast acuities at 70 and 40 cm; low-illumination, low-contrast acuity at 6 m; stereopsis at 40 cm; horizontal phorias at 3 m and 33 cm; and ±2.00 D monocular accommodative facility at 33 cm. Participants also rated (1-10 scale) vision quality (clarity and lack of ghosting for distance, intermediate, near, driving vision and vision stability during day- and night-time), overall vision satisfaction, ocular comfort, and willingness to purchase (yes/no response).
Results:
1-Day Acuvue Moist induced significantly (p<0.05) more negative SA at distance (Δ=0.078 μm) and near (Δ=0.064 μm) compared to the test lens, for a 6 mm pupil. There were no significant differences (p>0.05) in acuity, binocular vision, and all subjective metrics except vision stability between lenses where the test lens was rated to provide more stable vision (p<0.05).
Conclusion:
Contrary to expectations, incorporating negative SA in single vision soft contact lenses did not improve visual performance in non-presbyopic adult myopes.
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