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Inducement and Evaluation of a Murine Model of Experimental Myopia
Published on: January 22, 2019
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Myopia onset and role of peripheral refraction
Maurilia Rotolo1,2, Giancarlo Montani2, Raul Martin1,3
1Optometry Research Group, IOBA Eye Institute, School of Optometry, Universidad de Valladolid, Valladolid, Spain, raul@ioba.med.uva.es.
Clinical Optometry
|September 15, 2018
Summary
Peripheral refraction did not predict myopia onset or progression in Caucasian children over 18 months. Differences in relative peripheral refraction (RPR) were observed, but RPR is unlikely to be the sole driver of myopia progression treatments.
Area of Science:
- Ophthalmology
- Pediatric Optometry
- Myopia Research
Background:
- Investigating peripheral refraction in relation to refractive changes over 18 months in Caucasian children.
- Understanding the role of peripheral refraction in myopia development and progression.
Purpose of the Study:
- To determine peripheral refraction characteristics associated with 18-month refractive changes in Caucasian (Mediterranean) children.
- To assess if relative peripheral refraction (RPR) can predict myopia onset or progression.
Main Methods:
- Non-cycloplegic peripheral refraction measured at 10° intervals over the central ±30° horizontal visual field in 50 eight-year-old children over 18 months.
- Calculation of Relative Peripheral Refraction (RPR) and axial length (AL) measurements.
- Grouping of eyes into non-myopic, myopic, and those that developed myopia.
Main Results:
- Myopic eyes exhibited hyperopic RPR, while emmetropic and hyperopic eyes showed myopic RPR.
- No statistically significant effect of peripheral refraction or RPR on myopia onset was found.
- All groups showed axial length increase without significant inter-group differences.
Conclusions:
- A hyperopic relative peripheral shift change was observed in eyes that develop myopia.
- RPR differences exist between myopic and non-myopic eyes, but RPR does not predict myopia development or progression in this cohort.
- The efficacy of myopia control treatments targeting peripheral refraction may involve mechanisms beyond RPR alone.
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