Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Base Quantities and Derived Quantities01:14

Base Quantities and Derived Quantities

26.3K
In any system of units, the units for some physical quantities must be specified through a measurement process. These measurements are the base quantities of the system, and their units are the base units of the system. The algebraic combinations of the base values can then be used to express all other physical quantities. Each of these physical quantities is then referred to as a derived quantity, with each unit being referred to as a derived unit.
The International Organization for...
26.3K
Abnormal Proliferation02:23

Abnormal Proliferation

5.2K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.2K
Estimation of the Physical Quantities01:05

Estimation of the Physical Quantities

7.8K
On many occasions, physicists, other scientists, and engineers need to make estimates of a particular quantity. These are sometimes referred to as guesstimates, order-of-magnitude approximations, back-of-the-envelope calculations, or Fermi calculations. The physicist Enrico Fermi was famous for his ability to estimate various kinds of data with surprising precision. Estimating does not mean guessing a number or a formula at random. Instead, estimation means using prior experience and sound...
7.8K
Relating Angular And Linear Quantities - I01:09

Relating Angular And Linear Quantities - I

8.5K
If the rotational definitions are compared with the definitions of linear kinematic variables from motion along a straight line and motion in two and three dimensions, we can observe a mapping of the linear variables to the rotational ones.
When comparing the linear and rotational variables individually, the linear variable of position has physical units of meters, whereas the angular position variable has dimensionless units of radians, as it is the ratio of two lengths. The linear velocity...
8.5K
Relating Angular And Linear Quantities - II01:05

Relating Angular And Linear Quantities - II

6.6K
In the case of circular motion, the linear tangential speed of a particle at a radius from the axis of rotation is related to the angular velocity by the relation:
6.6K
Respiratory System Abnormal Finding I: Inspection and Percussion01:30

Respiratory System Abnormal Finding I: Inspection and Percussion

840
Respiratory system abnormalities are a significant concern in healthcare due to their potential to indicate underlying severe conditions like Chronic Obstructive Pulmonary Disease (COPD), asthma, and pneumonia. These abnormalities can often be detected through physical examination methods like inspection and percussion.
Inspection Findings
During an inspection, several findings may suggest the presence of respiratory distress or disease. Pursed-lip breathing, where exhalation is slowed by...
840

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Simultaneous Zn<sup>2+</sup> tracking in multiple organelles using super-resolution morphology-correlated organelle identification in living cells.

Nature communications·2021
Same author

Improving the thermostability of a GH11 xylanase by directed evolution and rational design guided by B-factor analysis.

Enzyme and microbial technology·2020
Same author

Progresses in clinical studies on antiviral therapies for COVID-19-Experience and lessons in design of clinical trials.

Pediatric investigation·2020
Same author

Coordination of Ligand-Protected Metal Nanoclusters and Glass Nanopipettes: Conversion of a Liquid-Phase Fluorometric Assay into an Enhanced Nanopore Analysis.

Analytical chemistry·2020
Same author

Evaluation of Cannabinoids on the Odonto/Osteogenesis in Human Dental Pulp Cells In Vitro.

Journal of endodontics·2020
Same author

The lncRNA <i>UBE2R2-AS1</i> suppresses cervical cancer cell growth <i>in vitro</i>.

Open medicine (Warsaw, Poland)·2020

Related Experiment Video

Updated: Feb 5, 2026

Application of Retinoic Acid to Obtain Osteocytes Cultures from Primary Mouse Osteoblasts
07:13

Application of Retinoic Acid to Obtain Osteocytes Cultures from Primary Mouse Osteoblasts

Published on: May 13, 2014

13.9K

Abnormal changes in the quantity and function of osteoblasts cultured

Shan Gao1, Huaquan Wang1, Huijuan Jiang1

  • 1Department of Hematology, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China.

Oncology Letters
|September 15, 2018
PubMed
Summary

Osteoblast quantity and activity are reduced in myelodysplastic syndromes (MDS) patients, correlating with disease severity. These bone marrow niche cells show altered signaling pathways in MDS.

Keywords:
Jagged 1bone marrow nichemyelodysplastic syndromeosteoblastsosteoprogenitors

More Related Videos

Drug Treatment and In Vivo Imaging of Osteoblast-Osteoclast Interactions in a Medaka Fish Osteoporosis Model
08:53

Drug Treatment and In Vivo Imaging of Osteoblast-Osteoclast Interactions in a Medaka Fish Osteoporosis Model

Published on: January 1, 2017

9.8K
Ex vivo Mimicry of Normal and Abnormal Human Hematopoiesis
11:50

Ex vivo Mimicry of Normal and Abnormal Human Hematopoiesis

Published on: April 10, 2012

16.0K

Related Experiment Videos

Last Updated: Feb 5, 2026

Application of Retinoic Acid to Obtain Osteocytes Cultures from Primary Mouse Osteoblasts
07:13

Application of Retinoic Acid to Obtain Osteocytes Cultures from Primary Mouse Osteoblasts

Published on: May 13, 2014

13.9K
Drug Treatment and In Vivo Imaging of Osteoblast-Osteoclast Interactions in a Medaka Fish Osteoporosis Model
08:53

Drug Treatment and In Vivo Imaging of Osteoblast-Osteoclast Interactions in a Medaka Fish Osteoporosis Model

Published on: January 1, 2017

9.8K
Ex vivo Mimicry of Normal and Abnormal Human Hematopoiesis
11:50

Ex vivo Mimicry of Normal and Abnormal Human Hematopoiesis

Published on: April 10, 2012

16.0K

Area of Science:

  • Hematology
  • Bone Biology
  • Cell Biology

Background:

  • Bone marrow niche alterations are implicated in myelodysplastic syndromes (MDS) pathogenesis.
  • Osteoblasts, crucial components of the bone marrow niche, play a significant role in MDS progression.

Purpose of the Study:

  • To investigate osteoblast quantity and function in MDS patients.
  • To identify changes in osteoblast signaling pathways and their association with MDS progression.

Main Methods:

  • Quantification of osteoprogenitors (CD34+OCN+) and osteoblasts (OCN+CD34-Lin-) in MDS patients and controls.
  • In vitro assays to assess osteoblast activity and signaling pathways (TIM3, Jagged 1) in MDS patient-derived cells.

Main Results:

  • MDS patients exhibited significantly lower ratios of osteoprogenitors and osteoblasts compared to normal controls.
  • Osteoblast quantity and activity were reduced in MDS patients, correlating with disease severity.
  • In vitro osteoblasts from high-risk MDS patients showed decreased quantity and increased levels of TIM3 and Jagged 1.

Conclusions:

  • Osteoblasts are abnormally altered in MDS patients.
  • These osteoblast abnormalities are associated with the severity of myelodysplastic syndromes.
  • Altered osteoblast function and signaling may contribute to MDS pathogenesis.