Related Experiment Video
Updated: Feb 5, 2026
18:08
Interview: Glycolipid Antigen Presentation by CD1d and the Therapeutic Potential of NKT cell Activation
Published on: December 31, 2007
10.4K
Genetics of antigen processing and presentation
Adrian Kelly1, John Trowsdale2
1Department of Pathology, University of Cambridge, Cambridge, CB21QP, UK.
Immunogenetics
|September 15, 2018
Summary
Genetic studies reveal how the immune system presents antigens. Understanding antigen processing and presentation pathways is crucial for immune response and disease. This involves major histocompatibility complex (MHC) molecules and other genetic factors.
Area of Science:
- Immunology
- Genetics
- Molecular Biology
Background:
- Immune response relies on coordinated molecular expression for disease recognition.
- Major histocompatibility complex (MHC) class I and class II molecules are critical for antigen specificity.
- Antigen processing involves multiple molecules, many encoded within the MHC region, such as TAP, proteasome, Tapasin, HLA-DO, and HLA-DM.
Purpose of the Study:
- To provide a historical overview of genetic approaches used to understand antigen processing and presentation.
- To highlight the role of genetic analysis in elucidating immune system mechanisms.
Main Methods:
- Analysis of MHC mutants, including point mutations and large deletions.
- Utilizing mouse genetics to study immune response pathways.
- Investigating microorganisms (viruses, bacteria) that interfere with antigen processing and presentation.
Main Results:
- Identification of numerous genes controlling antigen processing and presentation, including those regulating HLA class I and class II expression transcriptionally.
- Understanding the function of MHC-encoded genes like TAP, proteasome, Tapasin, HLA-DO, and HLA-DM.
- Insights gained from studying how pathogens evade immune recognition by targeting these pathways.
Conclusions:
- Genetic approaches, from traditional to modern, have been instrumental in deciphering complex antigen processing and presentation mechanisms.
- Continued genetic research is vital for advancing our understanding of immune responses and developing strategies against diseases.
More Related Videos
06:57Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells
Published on: September 18, 2016
9.6K
12:48Purification of the Membrane Compartment for Endoplasmic Reticulum-associated Degradation of Exogenous Antigens in Cross-presentation
Published on: August 21, 2017
8.6K
Related Concept Videos
01:29Processes of Self-Presentation
249
Effective self-presentation is a central component of social interaction and identity construction. It relies on the dynamic processes of defining the situation and engaging in self-disclosure. These mechanisms help individuals navigate social context expectations and manage how others perceive them, fostering mutual understanding and relationship development.Defining the SituationSocial situations are shaped by collectively understood frames—a set of widely understood rules or...
249
01:31Antigen Processing Pathways
2.3K
MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
MHC Class I: Presenting Endogenous...
MHC Class I: Presenting Endogenous...
2.3K
02:05Self-Presentation: Self-Monitoring and Self-Handicapping
44.8K
People can go to great lengths to protect their self-image and present themselves in ways that they want others to see them. Sociologist Erving Goffman presented the idea that a person is like an actor on a stage. Calling his theory dramaturgy, Goffman believed that we use “impression management” to present ourselves to others as we hope to be perceived. Each situation is a new scene, and individuals perform different roles depending on who is present (Goffman, 1959). Think about...
44.8K
01:25Self-Presentation
323
Self-presentation is a fundamental aspect of social interaction, shaping both how others perceive individuals and how they view themselves. This dynamic process influences behaviors in various social settings, often leading people to adjust their appearance, speech, and demeanor to align with their desired identity. While self-presentation can be deliberate or unconscious, it plays a critical role in interpersonal relationships and self-perception.Forms of Self-PresentationSelf-presentation can...
323
01:12Strategies of Self-Presentation I: Strategic Self-Presentation
220
Strategic self-presentation refers to individuals' intentional efforts to influence how others perceive them. This process is employed in various social and professional settings, such as job interviews, dating, politics, and legal contexts, where individuals seek to shape impressions to gain social or material advantages. While people generally present themselves in ways that align with their authentic characteristics, external factors, such as cognitive load, can hinder their ability to...
220
01:17Strategies of Self-Presentation II: Self-Verification
192
Self-verification is a fundamental psychological drive wherein individuals seek affirmation of their self-concept from others, striving for consistency between their internal self-view and external perceptions. This drive operates even when the self-concept is negative, influencing interpersonal behavior and feedback preferences in complex and often counterintuitive ways. Unlike the self-enhancement motive, which seeks positive evaluations, self-verification prioritizes coherence and...
192