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Related Concept Videos

Processes of Self-Presentation01:29

Processes of Self-Presentation

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Effective self-presentation is a central component of social interaction and identity construction. It relies on the dynamic processes of defining the situation and engaging in self-disclosure. These mechanisms help individuals navigate social context expectations and manage how others perceive them, fostering mutual understanding and relationship development.Defining the SituationSocial situations are shaped by collectively understood frames—a set of widely understood rules or...
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MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
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Self-Presentation: Self-Monitoring and Self-Handicapping02:05

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People can go to great lengths to protect their self-image and present themselves in ways that they want others to see them. Sociologist Erving Goffman presented the idea that a person is like an actor on a stage. Calling his theory dramaturgy, Goffman believed that we use “impression management” to present ourselves to others as we hope to be perceived. Each situation is a new scene, and individuals perform different roles depending on who is present (Goffman, 1959). Think about...
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Self-Presentation01:25

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Self-presentation is a fundamental aspect of social interaction, shaping both how others perceive individuals and how they view themselves. This dynamic process influences behaviors in various social settings, often leading people to adjust their appearance, speech, and demeanor to align with their desired identity. While self-presentation can be deliberate or unconscious, it plays a critical role in interpersonal relationships and self-perception.Forms of Self-PresentationSelf-presentation can...
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Strategies of Self-Presentation I: Strategic Self-Presentation01:12

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Strategic self-presentation refers to individuals' intentional efforts to influence how others perceive them. This process is employed in various social and professional settings, such as job interviews, dating, politics, and legal contexts, where individuals seek to shape impressions to gain social or material advantages. While people generally present themselves in ways that align with their authentic characteristics, external factors, such as cognitive load, can hinder their ability to...
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Strategies of Self-Presentation II: Self-Verification01:17

Strategies of Self-Presentation II: Self-Verification

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Self-verification is a fundamental psychological drive wherein individuals seek affirmation of their self-concept from others, striving for consistency between their internal self-view and external perceptions. This drive operates even when the self-concept is negative, influencing interpersonal behavior and feedback preferences in complex and often counterintuitive ways. Unlike the self-enhancement motive, which seeks positive evaluations, self-verification prioritizes coherence and...
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Genetics of antigen processing and presentation.

Adrian Kelly1, John Trowsdale2

  • 1Department of Pathology, University of Cambridge, Cambridge, CB21QP, UK.

Immunogenetics
|September 15, 2018
PubMed
Summary
This summary is machine-generated.

Genetic studies reveal how the immune system presents antigens. Understanding antigen processing and presentation pathways is crucial for immune response and disease. This involves major histocompatibility complex (MHC) molecules and other genetic factors.

Keywords:
Antigen presentationAntigen processingGeneticsHLAMHC

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Area of Science:

  • Immunology
  • Genetics
  • Molecular Biology

Background:

  • Immune response relies on coordinated molecular expression for disease recognition.
  • Major histocompatibility complex (MHC) class I and class II molecules are critical for antigen specificity.
  • Antigen processing involves multiple molecules, many encoded within the MHC region, such as TAP, proteasome, Tapasin, HLA-DO, and HLA-DM.

Purpose of the Study:

  • To provide a historical overview of genetic approaches used to understand antigen processing and presentation.
  • To highlight the role of genetic analysis in elucidating immune system mechanisms.

Main Methods:

  • Analysis of MHC mutants, including point mutations and large deletions.
  • Utilizing mouse genetics to study immune response pathways.
  • Investigating microorganisms (viruses, bacteria) that interfere with antigen processing and presentation.

Main Results:

  • Identification of numerous genes controlling antigen processing and presentation, including those regulating HLA class I and class II expression transcriptionally.
  • Understanding the function of MHC-encoded genes like TAP, proteasome, Tapasin, HLA-DO, and HLA-DM.
  • Insights gained from studying how pathogens evade immune recognition by targeting these pathways.

Conclusions:

  • Genetic approaches, from traditional to modern, have been instrumental in deciphering complex antigen processing and presentation mechanisms.
  • Continued genetic research is vital for advancing our understanding of immune responses and developing strategies against diseases.