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Knowledge Based Cloud FE Simulation of Sheet Metal Forming Processes
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HP-β-CD Functionalized Fe

Saijie Song1,2,3, Yu Chong4, Han Fu1

  • 1CAS Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine, CAS Center for Excellence in Nanoscience , Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences , Suzhou 215123 , China.

ACS Applied Materials & Interfaces
|September 15, 2018
PubMed
Summary
This summary is machine-generated.

Hydroxypropyl-β-cyclodextrin functionalized Fe3O4/carbon nanoparticles (HFCNPs) offer pH/NIR responsive drug release for combined chemo/photothermal therapy. This smart nanotheranostic approach enhances tumor inhibition and imaging-guided treatment.

Keywords:
carbon nanoparticleschemo/photothermal therapydual-modal imagingpH/NIR responsive drug releasetheranostic nanoplatform

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Oncology

Background:

  • Combined chemo/photothermal therapy shows superior antitumor effects compared to monotherapies.
  • Development of targeted nanocarriers is crucial for efficient drug delivery and therapy.

Purpose of the Study:

  • To develop functionalized nanoparticles for pH/NIR responsive drug release and dual-modal imaging-guided cancer therapy.
  • To evaluate the efficacy of combined chemo/photothermal therapy using these nanocarriers.

Main Methods:

  • Synthesis of hydroxypropyl-β-cyclodextrin functionalized Fe3O4/carbon nanoparticles (HFCNPs).
  • Loading of doxorubicin (DOX) onto HFCNPs with high capacity and controlled release mechanisms.
  • Utilizing MR/NIRFL dual-modal imaging for tumor visualization and tracking nanoparticle biodistribution.
  • Implementing chemo/photothermal therapy guided by NIR laser irradiation.

Main Results:

  • HFCNPs demonstrated high doxorubicin loading (61.2%) and controlled release under NIR irradiation and acidic conditions.
  • Dual-modal imaging effectively located tumors and tracked nanoparticle accumulation and retention.
  • Synergistic chemo/photothermal therapy achieved significant tumor inhibition due to enhanced drug permeation via NIR-induced heating.

Conclusions:

  • HFCNPs serve as effective nanocarriers for targeted drug delivery and controlled release.
  • The developed nanotheranostic system enables precise tumor imaging and combined therapeutic intervention.
  • This approach presents a promising strategy for developing smart, multimodal cancer-targeted nanotheranostics.