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FGF23 beyond Phosphotropic Hormone
Yuichi Takashi1, Seiji Fukumoto2
1Diabetes Therapeutics and Research Center, Institute of Advanced Medical Sciences, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima, Tokushima 7708503, Japan; Fujii Memorial Institute of Medical Sciences, Institute of Advanced Medical Sciences, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima, Tokushima 7708503, Japan.
Fibroblast growth factor (FGF) 23 regulates phosphate and vitamin D. This review explores FGF23 actions beyond the kidney, particularly its α-Klotho-independent roles in other tissues under disease conditions.
Area of Science:
- Endocrinology
- Mineral Metabolism
- Molecular Biology
Background:
- Fibroblast growth factor (FGF) 23 is a key hormone regulating phosphate and vitamin D.
- FGF23 primarily acts on kidneys through the FGF receptor (FGFR)/α-Klotho complex.
- Established roles in mineral homeostasis contrast with emerging, less understood actions in other tissues.
Purpose of the Study:
- To review recent findings on FGF23 actions in diverse tissues.
- To explore FGF23's mechanisms, especially α-Klotho-independent pathways.
- To identify knowledge gaps regarding FGF23's broader physiological and pathological roles.
Main Methods:
- Literature review of recent studies on FGF23.
- Analysis of FGF23 signaling pathways.
- Discussion of experimental evidence for FGF23 effects.
Main Results:
- FGF23 exhibits significant physiological roles in mineral metabolism.
- Emerging evidence points to FGF23's diverse effects in non-kidney tissues.
- α-Klotho-independent FGF23 actions are increasingly recognized, particularly in disease states.
Conclusions:
- FGF23's functions extend beyond mineral metabolism and kidney regulation.
- Understanding α-Klotho-independent FGF23 signaling is crucial for elucidating its full impact.
- Further research is needed to clarify FGF23's complex roles in various tissues and pathologies.
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