Related Experiment Video
Updated: Feb 5, 2026

Assessment of the Immunomodulatory Properties of Human Mesenchymal Stem Cells MSCs
Published on: December 24, 2015
Uptake-release by MSCs of a cationic platinum(II) complex active in vitro on human malignant cancer cell lines
Isabella Rimoldi1, Valentina Coccè2, Giorgio Facchetti1
1Department of Pharmaceutical Science, University of Milan, Via Venezian 21, 20133 Milan, Italy.
Abstract:
In this study, the in vitro stability of cisplatin (CisPt) and cationic platinum(II)-complex (caPt(II)-complex) and their in vitro activity (antiproliferative and anti-angiogenic properties) were investigated against three aggressive human tumor cell lines. caPt(II)-complex shown a high stability until 9 days of treatment and displayed a significant and higher activity than CisPt against both NCI-H28 mesothelioma (19.37 ± 9.57 μM versus 34.66 ± 7.65 μM for CisPt) and U87 MG glioblastoma (19.85 ± 0.97 μM versus 54.14 ± 3.19 for CisPt). Mesenchymal Stromal Cells (AT-MSCs) showed a significant different sensitivity (IC50 = 71.9 ± 15.1 μM for caPt(II)-complex and 8.7 ± 4.5 μM for CisPt) to the antiproliferative activity of caPt(II)-complex and CisPt. The ability of MSCs to uptake both the drugs in a similar amount of 2.49 pM /cell, suggested a possible development of new therapies based on cell mediated drug delivery.
Related Concept Videos
Drugs Affecting Neurotransmitter Release or Uptake
Cell Lines
Protein Complex Assembly
Many viruses self-assemble into a fully functional unit using the infected host cell to...
In Vitro Drug Release Testing: Overview, Development and Validation
Lossless Lines
Activation Energy

