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Semi-quantitative Assessment Using [18F]FDG Tracer in Patients with Severe Brain Injury
Published on: November 9, 2018
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Polymorphonuclear (PMN) elastase in patients after severe traumatic brain injury
Lukas Kurt Postl1, Viktoria Bogner2, Martijn van Griensven3
1Department of Trauma Surgery, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675, Munich, Germany. lukas.postl@tum.de.
European Journal of Medical Research
|September 17, 2018
Summary
Cerebrospinal fluid (CSF) neutrophil elastase levels significantly increase 48 and 72 hours after traumatic brain injury (TBI). The blood-cerebrospinal fluid barrier integrity did not influence these elevated PMN elastase levels in TBI patients.
Area of Science:
- Neuroscience
- Biochemistry
- Trauma Research
Background:
- Limited data exists on neutrophil elastase (PMN elastase) levels in cerebrospinal fluid (CSF) post-traumatic brain injury (TBI).
- Understanding these levels is crucial for assessing inflammatory responses following TBI.
Purpose of the Study:
- To prospectively evaluate the dynamic changes of PMN elastase in CSF after TBI in humans.
- To investigate the potential influence of blood-cerebrospinal fluid barrier (BCSFB) integrity on PMN elastase levels.
Main Methods:
- Prospective study enrolling TBI patients with Glasgow Coma Scale ≤ 8 and intracerebral hemorrhage.
- CSF and blood samples collected at multiple time points (0, 12, 24, 48, 72 hours).
- ELISA used for PMN elastase quantification; CSF/serum albumin ratio assessed BCSFB function.
Main Results:
- PMN elastase levels showed a significant elevation at 48 and 72 hours post-TBI.
- No significant difference in PMN elastase levels was observed between patients with intact and defective BCSFB.
- Control group CSF samples were obtained from patients undergoing spinal anesthesia.
Conclusions:
- This study is the first to report significantly increased CSF PMN elastase levels in the early post-TBI phase (48-72 hours).
- BCSFB function does not appear to significantly influence PMN elastase levels in the early stages after TBI.
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