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Use of the Operant Orofacial Pain Assessment Device OPAD to Measure Changes in Nociceptive Behavior
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Chronic orofacial pain animal models - progress and challenges.
Heitor G Araújo-Filho1, Erik W M Pereira1, Adriana Rolim Campos2
1a Laboratory of Neuroscience and Pharmacological Assays (LANEF), Department of Physiology , Federal University of Sergipe , São Cristóvão , Brazil.
Expert Opinion on Drug Discovery
|September 18, 2018
Summary
Animal models are crucial for understanding chronic orofacial pain (COFP) and developing new treatments. Selecting appropriate models enhances drug discovery and clinical translation for this disabling condition.
Area of Science:
- Pain research
- Neuroscience
- Pharmacology
Background:
- Chronic orofacial pain (COFP) is a prevalent condition in adults.
- Animal models are vital for investigating COFP pathophysiology and therapeutic development.
- Improving existing and creating new models is essential for advancing pain research.
Purpose of the Study:
- To review and discuss various animal models for chronic orofacial pain (COFP).
- To examine the mechanisms underlying orofacial neuropathic and inflammatory pain.
- To highlight the advantages and challenges of using animal models in COFP drug discovery.
Main Methods:
- Literature review and discussion of established and emerging animal models for COFP.
- Analysis of mechanisms involved in orofacial neuropathic and inflammatory pain models.
- Evaluation of the utility of animal models in preclinical research for COFP.
Main Results:
- A range of animal models are available for studying COFP.
- Key mechanisms of orofacial neuropathic and inflammatory pain have been elucidated through these models.
- Animal models offer significant benefits for COFP drug discovery and treatment development.
Conclusions:
- The selection of appropriate animal models is critical for successful translation of preclinical findings to clinical practice.
- Genetically modified animal models show promise but require further development for COFP research.
- Despite advancements, challenges remain in optimizing animal models for effective orofacial pain treatments.
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