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Effect of 2.45 GHz microwave radiation on the fertility pattern in male mice

Chhoteylal Jonwal1, Rashmi Sisodia, Virandra K Saxena

  • 1Department of Zoology, University of Rajasthan, Jaipur, Rajasthan, India. rashsisodia@yahoo.co.in.

General Physiology and Biophysics
|September 18, 2018
PubMed

Insights

Microwave radiation exposure significantly increases oxidative stress and harms male reproductive health in mice. This study highlights potential risks to fertility from electromagnetic fields (EMFs).

Area of Science:

  • Reproductive Biology
  • Environmental Health
  • Toxicology

Background:

  • Male reproductive organs are known to be sensitive to electromagnetic fields (EMFs).
  • Previous research indicates potential adverse effects of EMFs on male fertility.

Purpose of the Study:

  • To investigate the impact of 2.45 GHz microwave radiation on the male reproductive system of Swiss albino mice.
  • To assess oxidative stress markers, hormone levels, and histopathological changes in testes following microwave exposure.

Main Methods:

  • Male Swiss albino mice (6-8 weeks old) were divided into sham-exposed (Control) and microwave-exposed (MWs) groups.
  • Mice were exposed to 2.45 GHz microwave radiation (0.25 mW/cm2, SAR 0.09 W/kg) for 2 hours daily over 30 days.
  • Evaluated biochemical markers (CAT, MDA, ROS, GPx, SOD), testosterone levels, blood micronuclei formation, and testicular histopathology.

Main Results:

  • Microwave exposure significantly increased oxidative stress markers: catalase (CAT), malondialdehyde (MDA), and reactive oxygen species (ROS).
  • A significant decrease was observed in antioxidant enzymes glutathione peroxidase (GPx), superoxide dismutase (SOD), and testosterone levels.
  • Microwave exposure led to the formation of micronuclei in blood cells and caused histopathological damage to seminiferous tubules.

Conclusions:

  • 2.45 GHz microwave radiation exposure induces significant oxidative stress in the testes of male mice.
  • These findings suggest that microwave exposure may have detrimental effects on male reproductive function and fertility potential.

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