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Updated: Feb 5, 2026
05:05
Generating a Murine Orthotopic Metastatic Breast Cancer Model and Performing Murine Radical Mastectomy
Published on: November 29, 2018
11.7K
Cure in metastatic breast cancer
Theresa Westphal1,2,3, Simon Peter Gampenrieder1,2,3, Gabriel Rinnerthaler1,2,3
11IIIrd Medical Department with Hematology and Medical Oncology, Oncologic Center, Paracelsus Medical University Salzburg, Müllner Hauptstraße 48, 5020 Salzburg, Austria.
Memo
|September 18, 2018
Summary
Oligometastatic breast cancer patients may achieve long-lasting remission with multimodal therapy. This review explores locoregional treatments, systemic therapies, and immunotherapy for potential cure in select cases.
Area of Science:
- Oncology
- Cancer Research
Background:
- Oligometastatic breast cancer represents a unique patient group with potential for long-term remission or cure.
- Existing data on curative-intent treatments are primarily from case series, lacking prospective evidence.
Purpose of the Study:
- To review current data on achieving long-lasting remissions and potential cure in metastatic breast cancer.
- To discuss the role of locoregional treatment, systemic therapies, and immunotherapy.
Main Methods:
- Literature review of case series and prospective data on metastatic breast cancer treatments.
- Analysis of data concerning locoregional interventions, chemotherapy, antibody therapy, and immunotherapy.
- Identification of patient subgroups potentially benefiting from multidisciplinary curative-intent approaches.
Main Results:
- Long-lasting remissions have been observed following locoregional treatment of primary tumors and metastases.
- Novel systemic therapies (chemotherapy, targeted agents) can lead to long-term survival.
- Immunotherapy, particularly checkpoint inhibitors, shows limited response rates as monotherapy but holds potential for tumor control.
Conclusions:
- A multidisciplinary approach integrating locoregional treatment, systemic therapy, and immunotherapy may offer curative potential for select oligometastatic breast cancer patients.
- Further prospective studies are needed to validate treatment strategies for achieving long-term survival and cure.
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