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Heating it up: Oncolytic viruses make tumors 'hot' and suitable for checkpoint blockade immunotherapies
Shashi Gujar1,2,3,4, Jonathan G Pol5,6,7,8,9, Guido Kroemer5,6,7,8,9,10,11,12
1Department of Pathology, Dalhousie University, Halifax, NS, Canada.
Oncoimmunology
|September 18, 2018
Abstract:
Immune checkpoint blockade is less efficient in patients bearing immunologically 'cold' tumors. Oncolytic viruses, which were originally discovered for their ability to preferentially kill malignant cells, can recondition the tumor microenvironment. Supporting this hypothesis, two new studies published in Science Translational Medicine show that adjuvant-like activities of oncolytic viruses make brain and breast tumors 'hot' and sensitize them for subsequent immune checkpoint blockade.