Related Experiment Video

Updated: Feb 5, 2026

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
08:03

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Published on: December 1, 2016

9.5K

Efficacy and safety of immune checkpoint inhibitors in non-small cell lung cancer

Shuai Wang1, Jiatao Hao2, Hao Wang1

  • 1Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.

Oncoimmunology
|September 18, 2018
PubMed

Insights

Immune checkpoint inhibitors (ICIs) significantly improve survival and response rates in non-small cell lung cancer (NSCLC). These therapies show fewer adverse effects, establishing them as a preferred treatment for specific NSCLC patient groups.

Area of Science:

  • Oncology
  • Immunotherapy
  • Clinical Trials

Background:

  • Non-small cell lung cancer (NSCLC) is a leading cause of cancer mortality.
  • Immune checkpoint inhibitors (ICIs) represent a novel therapeutic class for NSCLC.
  • Quantitative evaluation of ICI efficacy and safety in NSCLC is crucial.

Purpose of the Study:

  • To quantitatively assess the efficacy and safety of immune checkpoint inhibitors (ICIs) in non-small cell lung cancer (NSCLC).
  • To identify patient subgroups that benefit most from ICI therapy.

Main Methods:

  • Systematic search of PubMed, Embase, Cochrane Library, and Web of Science for randomized clinical trials.
  • Meta-analysis of 12 trials including 6,919 NSCLC patients, adhering to PRISMA guidelines.
  • Pooled analysis of progression-free survival (PFS), overall survival (OS), objective response rates (ORR), and adverse events.

Main Results:

  • ICIs significantly improved PFS (HR 0.838), OS (HR 0.747), and ORR (RR 1.311) in NSCLC patients.
  • Benefits were observed across various demographics and clinical factors, but were limited in non-smokers, patients with CNS metastasis, EGFR mutations, or low PD-L1 expression.
  • ICIs demonstrated a reduced risk of several adverse events, including anemia, neutropenia, and nausea, compared to control therapies.

Conclusions:

  • Immune checkpoint inhibitors (ICIs) enhance PFS, OS, and ORR in NSCLC patients with a favorable safety profile.
  • ICIs are a preferred treatment option for NSCLC patients who are smokers, have no CNS metastasis, wild-type EGFR, and high PD-L1 expression.
Keywords:
PD-1PD-L1checkpoint inhibitorsimmunotherapylung cancermeta analysis

More Related Videos

Radiosensitivity of Cancer Stem Cells in Lung Cancer Cell Lines09:45

Radiosensitivity of Cancer Stem Cells in Lung Cancer Cell Lines

Published on: August 21, 2019

7.5K
Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice06:32

Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice

Published on: September 19, 2016

11.1K

Related Concept Videos

The Spindle Assembly Checkpoint02:19

The Spindle Assembly Checkpoint

The spindle assembly checkpoint is a molecular surveillance mechanism ensuring the fidelity of chromosome segregation during anaphase. The checkpoint monitors the completion of all the prerequisite steps before chromosome segregation to determine whether the segregation process should proceed or be delayed.
Many proteins function together to control the spindle assembly checkpoint. Mutations affecting these proteins may allow cells to proceed into anaphase prematurely, resulting in the...
3.9K
Survey Safety01:28

Survey Safety

Surveying near highways, rough terrain, or power lines involves significant risks. Working along highways is particularly dangerous and requires the use of warning signs and flagmen. It is safest to avoid working directly on roads and use offsets whenever possible. When highway work is unavoidable, it must follow all safety guidelines. Surveyors should wear bright clothing, such as orange reflective vests, to ensure visibility to motorists, coworkers, and hunters. In construction zones, wearing...
398
Eukaryotic Transcription Inhibitors01:52

Eukaryotic Transcription Inhibitors

Certain biochemical processes, such as embryonic development and cell growth regulation, depend on the repression of specific genes. DNA binding proteins known as eukaryotic transcription inhibitors regulate the repression of gene expression in eukaryotes. The presence of these inhibitors at the required location and time in the cell is triggered by the presence of hormones and additional signals from other cells.
Eukaryotic transcription inhibitors usually contain two distinct domains, a...
11.0K
What is the Immune System?01:38

What is the Immune System?

Overview
129.7K
Self-Efficacy01:29

Self-Efficacy

Self-efficacy is the belief in one's capacity to organize and execute actions necessary to manage prospective situations. This belief significantly influences how individuals approach goals, tasks, and challenges across different domains of life.Psychological and Educational ImpactsIndividuals with strong self-efficacy are more resilient in the face of difficulties. They are more likely to adopt effective problem-solving strategies, persist through obstacles, and regulate emotions such as...
230
Lung Capacity01:47

Lung Capacity

The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
56.3K