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Personal history of infections and immunotherapy: Unexpected links and possible therapeutic opportunities

Camille Jacqueline1,2, Nathalie Bonnefoy3, Guillaume M Charrière4

  • 1Centre for Ecological and Evolutionary Research on Cancer (CREEC), Montpellier, France.

Oncoimmunology
|September 18, 2018
PubMed

The recent breakthroughs in the understanding of tumor immune biology have given rise to a new generation of immunotherapies, harnessing the immune system to eliminate tumors. As the typology and frequency of encountered infections are susceptible to shape the immune system, it could also impact the efficiency of immunotherapy. In this review, we report evidences for an indirect link between personal history of infection and different strategies of immunotherapy. In the current context of interest rise for personalized medicine, we discuss the potential medical applications of considering personal history of infection to design immunotherapeutic strategies.

Keywords:
Adoptive cell transferCancer vaccineImmune checkpointsImmunotherapyInfectionsPersonalized medicine

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