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Area of Science:

  • Medical Imaging
  • Radiotherapy Technology
  • Biomedical Engineering

Background:

  • Fixed-gantry cone-beam computed tomography (CBCT) systems offer potential for compact and affordable linear accelerators (linacs).
  • Imaging with a rotating subject in a fixed-gantry setup presents reconstruction challenges due to gravity-induced motion.
  • Previous research has not explored the feasibility of fixed-gantry CBCT with live subjects.

Purpose of the Study:

  • To investigate the feasibility of fixed-gantry CBCT using live rabbit imaging data.
  • To develop and evaluate a novel motion correction technique for fixed-gantry CBCT.
  • To assess the image quality and accuracy of motion-corrected fixed-gantry CBCT.

Main Methods:

  • Acquired fixed-gantry CBCT scans of three live rabbits on a standard radiotherapy system with continuous rotation.
  • Developed a data-driven motion correction method combining partial-view reconstruction and motion compensation.
  • Validated reconstructed images against conventional CBCT scans, analyzing motion blur and anatomical accuracy.

Main Results:

  • Uncorrected scans showed severe motion blur due to gravity-induced motion.
  • The proposed motion correction method reduced gravity-induced motion blur to <1 mm.
  • Anatomical structures were reconstructed with <0.5 mm accuracy, with translational motion being the primary contributor.
  • The corrected reconstruction represented the time-averaged thoracic region location.

Conclusions:

  • Fixed-gantry CBCT is feasible in live subjects, demonstrated through rabbit imaging.
  • The developed motion correction technique yields clinically usable image quality and high accuracy.
  • This approach supports the development of compact fixed-gantry radiotherapy systems, with future validation in human subjects planned.