Dynamic Kinetic Resolution for Construction of Three Transannular Stereocenters of Dihydrobenzofuranols
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Published on: June 14, 2017
Lizhen Fang1, Fangfei Zhao1, Shuyu Hu1
1School of Pharmacy , Xinxiang Medical University , Xinxiang , Henan 453003 , People's Republic of China.
Abstract:
A handy and effective method was established to obtain the cis-2,3-dihydrobenzofuranols having three stereocenters, involving asymmetric transfer hydrogenation of benzofuranones via dynamic kinetic resolution. The general applicability of this method was examined with different benzofuran-3-(2 H)-ones, and stereoselectivities of 85-99% ee and up to 98/2 dr were obtained.
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