Related Experiment Video
Updated: Feb 5, 2026

Design and Use of a Low Cost, Automated Morbidostat for Adaptive Evolution of Bacteria Under Antibiotic Drug Selection
Published on: September 27, 2016
Effective Drug Supply for Adaptive Clinical Trials: Recommendations by the DIA Adaptive Design Scientific Working
Nancy Burnham1, Judith Quinlan2, Weili He3
11 Hambel Statistical Consulting LLC, Wayne, PA, USA.
Abstract:
During the past decade, there has been increasing interest in adaptive clinical trials in pharmaceutical drug development as a means to improved decision making, better dose selection, and reduction in cost and time to market. Nevertheless, the operational challenge of drug supply continues to be a barrier preventing greater uptake of adaptive designs. Such studies require the ability to quickly accommodate changes in treatment allocation while maintaining the integrity of the blind. The DIA Adaptive Design Scientific Working Group formed a subteam to discuss solutions to the drug supply dilemma. In this paper, the subteam discusses effective strategies for drug manufacturing, labeling, packaging, and randomization and addresses financial concerns.
Related Concept Videos
Nerve Supply of the GI Tract
The enteric nervous system consists of two major plexuses: the myenteric plexus (Auerbach's plexus) and the submucosal plexus (Meissner's plexus). These plexuses are located within the layers of...
Blood Supply to the Digestive System
Blood Supply to the Digestive System: The splanchnic circulation involves three main arteries: the celiac artery (also known as the celiac trunk) and the superior and inferior mesenteric...
Clinical Trials
There are four phases in a clinical trial. A phase one...
Energy Supply for Muscle Contraction
Blood and Nerve Supply to the Bones
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
Clinical Trials: Overview

