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Updated: Feb 5, 2026
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Author Spotlight: Advancing VRL Diagnosis Using Cell-Free DNA Extraction from Vitreous Humor
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Primary Vitreoretinal Lymphoma Presenting as a Posterior Capsule Plaque
Ophthalmic Surgery, Lasers & Imaging Retina
|September 18, 2018
Summary
Primary vitreoretinal lymphoma (PVRL) is difficult to diagnose, often mimicking other inflammatory eye conditions. This case highlights PVRL
Area of Science:
- Ophthalmology
- Neurology
- Oncology
Background:
- Primary vitreoretinal lymphoma (PVRL) presents diagnostic challenges, often mimicking inflammatory eye diseases.
- Early symptoms can include steroid-responsive vitritis or subretinal infiltrates.
Observation:
- A patient initially presented with bilateral vitritis, unresponsive to standard diagnostic methods.
- Following a 2.5-year loss to follow-up, the patient developed a white plaque on an intraocular lens capsule.
- The vitreous cavity was clear, but a repeat biopsy confirmed diffuse large B-cell lymphoma.
Findings:
- The repeat biopsy confirmed diffuse large B-cell lymphoma (DLBCL).
- A concurrent brain MRI revealed a cerebellar lesion, indicative of primary central nervous system lymphoma (PCNSL).
Implications:
- This case underscores the importance of considering PVRL in persistent or unusual ocular inflammation.
- Delayed diagnosis can lead to disease progression and concurrent CNS involvement.
- Multidisciplinary approaches are crucial for diagnosing and managing complex cases of PVRL and PCNSL.
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