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Updated: Feb 5, 2026

Transpupillary-Guided Trans-Scleral Transplantation of Subretinal Grafts in a Retinal Degeneration Mouse Model
Published on: January 26, 2024
Closure of Large Chronic Macular Hole by Scleral Imbrication and Retinal Expansion
Background And Objective:
The purpose of this study is to describe a new technique for the treatment of large, chronic macular hole (MH) using scleral imbrication and retinal expansion and to report the outcomes of MH closure.
Patients And Methods:
This retrospective study demonstrates a procedure for correcting the disproportion between an area of stiff neurosensory retina and the inner scleral wall. Baseline MH parameters were collected. MH closure rate, visual outcomes, and biometry were reported at 6-month follow-up.
Results:
MH closure was achieved in six out of seven patients (85.7%). Mean minimal hole diameter, base hole diameter, and MH index were 712 μm ± 136.8 μm, 1,440 μm ± 444 μm, and 0.27 μm ± 0.08 μm, respectively. At 6-month follow-up, median logarithm of the minimum angle of resolution (logMAR) corrected distance visual acuity significantly improved from 1.2 (interquartile range [IQR] = 1.0 to 1.6) preoperatively to 0.7 (IQR = 0.58 to 0.8) postoperatively (P = .018; Wilcoxon signed-rank test).
Conclusion:
This technique provided both satisfactory hole closure rates and acceptable structural outcomes. [Ophthalmic Surg Lasers Imaging Retina. 2018;49:e57-e64.].
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