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A Systematic Review of Genetic Influence on Psychological Resilience
Kosuke Niitsu1, Michael J Rice1, Julia F Houfek2
11 College of Nursing, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Biological Research for Nursing
|September 19, 2018
Summary
This review identifies genetic variants linked to psychological resilience, finding specific genotypes in serotonin transporter (5-HTTLPR) and brain-derived neurotrophic factor (BDNF) genes associated with adaptation to adversity.
Area of Science:
- Genetics
- Psychology
- Neuroscience
Background:
- Resilience is the ability to adapt well to adversity.
- Psychological resilience is a complex biopsychosocial phenomenon.
- Genetic factors, including gene variants, epistasis, epigenetics, and gene-by-environment interactions, influence resilience.
Purpose of the Study:
- To identify specific genetic variants contributing to psychological resilience.
- To review empirical studies on the genetic basis of resilience.
Main Methods:
- Systematic literature search of PubMed and PsycINFO using keywords: psychological resilience AND genotype(s).
- Additional search in Human Genome Epidemiology Navigator using the term resilience, psychological.
- Inclusion criteria resulted in ten studies for review.
Main Results:
- Six genes were empirically associated with psychological resilience: 5-HTTLPR, dopamine receptor D4, BDNF, corticotropin-releasing hormone receptor 1, oxytocin receptor, and regulator of G-protein signaling 2.
- Specific genotypes of 5-HTTLPR (L/L or L'/L' in children/adolescents; S/S or S'/S' in adults) and BDNF (Val/Val genotype of rs6265 in Caucasians) were associated with resilience.
Conclusions:
- Genetic variants, particularly in 5-HTTLPR and BDNF, play a role in psychological resilience.
- Further research is needed to fully understand the genetic influences on resilience due to complexities like epistasis and epigenetics.
Keywords:
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