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Sedation, Delirium, and Cognitive Function After Critical Illness.
1Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, 638 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA.
Critical Care Clinics
|September 19, 2018
Summary
Delirium is a risk factor for critical illness brain injury. This review examines how sedation, a controllable factor, impacts delirium and long-term cognitive outcomes in ICU patients.
Area of Science:
- Critical care medicine
- Neuroscience
- Pharmacology
Background:
- Delirium is a known risk factor for critical illness brain injury.
- ICU patients face numerous delirium risk factors, complicating targeted interventions for cognitive outcomes.
- Sedating medications are frequently used in ICUs and are a modifiable risk factor for delirium.
Purpose of the Study:
- To explore the theoretical links between sedation, delirium, and long-term cognitive function in critically ill patients.
- To review existing evidence supporting the relationship between sedation, delirium, and cognitive outcomes.
Main Methods:
- This study is a review of theoretical relationships and existing evidence.
- Literature search on sedation, delirium, and cognitive outcomes in the ICU setting.
Main Results:
- Sedation is a direct, clinician-controlled risk factor for delirium.
- The relationship between sedation, delirium, and long-term cognition is of significant clinical and research interest.
Conclusions:
- Understanding the impact of sedation on delirium is crucial for improving long-term cognitive outcomes in ICU survivors.
- Further research is needed to elucidate the complex interplay between sedation, delirium, and cognitive trajectories post-critical illness.
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