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Related Experiment Video

Updated: Feb 5, 2026

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Mahdi Abastabar1, Iman Haghani1, Tahereh Shokohi1

  • 1Invasive Fungi Research Center (IFRC), School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

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|September 19, 2018
PubMed
Summary
This summary is machine-generated.

Tavaborole showed limited in vitro antifungal activity against common onychomycosis pathogens compared to standard treatments. This suggests tavaborole may not be effective for treating nail infections caused by Candida, Aspergillus, or dermatophytes.

Keywords:
antifungalonychomycosistavaborole

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Area of Science:

  • Mycology
  • Dermatology
  • Pharmacology

Background:

  • Onychomycosis is a common fungal nail infection.
  • Standard treatments include itraconazole, terbinafine, and fluconazole.
  • Tavaborole is an FDA-approved antifungal agent.

Purpose of the Study:

  • To compare the in vitro antifungal activity of tavaborole against clinical isolates from onychomycosis patients.
  • To evaluate tavaborole's efficacy relative to established antifungal drugs.

Main Methods:

  • 170 clinical fungal isolates from onychomycosis patients were used.
  • In vitro antifungal activity of tavaborole was tested against these isolates.
  • Activity was compared to four other antifungal agents, including itraconazole, terbinafine, and fluconazole.

Main Results:

  • Tavaborole demonstrated low in vitro activity against all tested fungal isolates.
  • Its activity was significantly lower compared to itraconazole, terbinafine, and fluconazole.
  • These results indicate a lack of potent antifungal effect by tavaborole in this study.

Conclusions:

  • Tavaborole is not a suitable candidate for treating onychomycosis.
  • This applies to infections caused by Candida species, Aspergillus species, and dermatophytes.
  • Current standard antifungal treatments appear more effective based on this in vitro data.