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Updated: Feb 5, 2026

Ultrahigh Resolution Mouse Optical Coherence Tomography to Aid Intraocular Injection in Retinal Gene Therapy Research
Published on: November 2, 2018
Translational Retinal Research and Therapies
Alison J Hardcastle1, Paul A Sieving2, José-Alain Sahel3
1Professor of Molecular Genetics, UCL Institute of Ophthalmology, London, UK.
This review covers gene therapy advancements for inherited retinal diseases, focusing on translating laboratory research into clinical applications for vision restoration. It highlights progress in treating retinal conditions to improve patient outcomes.
Area of Science:
- Ophthalmology
- Translational Medicine
- Gene Therapy
Background:
- The review stems from a symposium honoring Dr. Gustavo Aguirre, a Proctor Medal recipient.
- It focuses on the progress of gene therapy for inherited retinal diseases.
Purpose of the Study:
- To summarize the current state of gene therapy and translational medicine.
- To highlight the transition of laboratory research to clinical applications for retinal diseases.
Main Methods:
- Review of current research presented at a symposium.
- Focus on translational aspects of gene therapy for retinal conditions.
Main Results:
- Significant progress in moving retinal gene therapies from research to clinical settings.
- Current work on therapies for inherited retinal degenerative diseases.
Conclusions:
- Gene therapy holds promise for treating inherited retinal diseases.
- Translational research is crucial for developing effective clinical treatments for vision loss.
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Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of...
Translation
Translation Produces the Building Blocks of Life
Proteins are...
Initiation of Translation
First, the initiator tRNA must be selected from the pool of elongator tRNAs by eukaryotic initiation factor 2 (eIF2). The initiator tRNA (Met-tRNAi) has conserved sequence elements including modified bases at...
Gene Therapy
Termination of Translation
Termination of Translation

