Synthesis and Evaluation of Biological Activity of New Arylphosphoramidates
Amal Thebti1, M A K Sanhoury2, H-I Ouzari1
1LR03ES03 Laboratoire des Microorganismes et Biomolécules Actives, Département de Biologie, Faculté des Sciences de Tunis, Université ElManar, 2092, Tunisia.
Abstract:
The synthesis of new substituted arylphosphoramidates is performed in two steps through phosphorylation of the corresponding alcohols followed by aminolysis. The formation of the desired phosphoramidates depends on the subsequent addition of the two alcohols with the amine being added at the last step. The products were obtained in 58-95% yields. They were characterized mainly by multinuclear (1H, 13C, 31P, and 19F) NMR and IR spectroscopy. In addition, the antimicrobial and antiacetylcholinesterase activities were evaluated. The results showed acetylcholinesterase activity by some compounds, whilst no significant inhibitory effect against the tested bacterial strains has been recorded.
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