Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

14.9K
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
14.9K
Chemiosmosis01:32

Chemiosmosis

114.5K
Oxidative phosphorylation is a highly efficient process that generates large amounts of adenosine triphosphate (ATP), the basic unit of energy that drives many cellular processes. Oxidative phosphorylation involves two processes— the electron transport chain and chemiosmosis.
Electron Transport Chain
The electron transport chain involves a series of protein complexes on the inner mitochondrial membrane that undergo a series of redox reactions. At the end of this chain, the electrons...
114.5K
Chromosome Replication02:31

Chromosome Replication

10.7K
Before a cell can divide, it must accurately replicate all of its chromosomes, including the DNA and its associated histone and non-histone proteins.  This process begins at numerous origins of replication during the S phase of the cell cycle in each of a cell’s chromosomes simultaneously. Certain nucleotides can act as origins of replication, but these sequences are not well defined - especially in complex, multi-cellular, eukaryotic species. The length of DNA that spans an origin...
10.7K
Chromosome Structure02:40

Chromosome Structure

26.5K
A functional eukaryotic chromosome must contain three elements: a centromere, telomeres, and numerous origins of replication.
The centromere is a DNA sequence that links sister chromatids. This is also where kinetochores, protein complexes to which spindle microtubules attach, are constructed after the chromosome is replicated. The kinetochores allow the spindle microtubules to move the chromosomes within the cell during cell division.
Telomeres consist of non-coding repetitive nucleotide...
26.5K
Formation of Species01:31

Formation of Species

45.2K
Speciation describes the formation of one or more new species from one or sometimes multiple original species. The resulting species are discrete from the parent species, and barriers to reproduction will typically exist. There are two primary mechanisms, speciation with and without geographic isolation—allopatric and sympatric speciation, respectively.
45.2K
Replication in Eukaryotes02:31

Replication in Eukaryotes

205.1K
Overview
205.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Diverse excess GABA modes drive autism and epilepsy-autism comorbidity.

Journal of neural transmission (Vienna, Austria : 1996)·2026
Same author

Ephaptic conduction molding memory engrams.

BMC biology·2025
Same author

Sudden cardiac death prevention in the era of novel heart failure medications.

American heart journal plus : cardiology research and practice·2024
Same author

Possible mechanism of schizophrenia origin by excess GABA and synaptic pruning.

IBRO neuroscience reports·2023
Same author

A possible new cardiac heterogeneity as an arrhythmogenic driver.

Scientific reports·2023
Same author

Percolation and tortuosity in heart-like cells.

Scientific reports·2021
Same journal

Mathematical Modeling Shows that Overall Infection Burden is Reduced More by Vaccines that Decrease Spread or Accelerate Recovery than those that Lower Severe Infections or Death.

Bulletin of mathematical biology·2026
Same journal

Effects of Seasonal Births and Predation on Disease Spread.

Bulletin of mathematical biology·2026
Same journal

Identifiability, Sensitivity, and Genetic Algorithms in Bacterial Biofilm Selection Models.

Bulletin of mathematical biology·2026
Same journal

Slow Evolution Towards Generalism in a Model of Variable Dietary Range.

Bulletin of mathematical biology·2026
Same journal

CBINN: Cancer Biology-Informed Neural Network for Unknown Parameter Estimation and Missing Physics Identification.

Bulletin of mathematical biology·2026
Same journal

A Cost-Sensitive Behavioral Modeling Analysis of the Early Identification and Control of Infectious Diseases.

Bulletin of mathematical biology·2026
See all related articles

Related Experiment Video

Updated: Feb 5, 2026

Fluorescence Lifetime Imaging of Molecular Rotors in Living Cells
09:45

Fluorescence Lifetime Imaging of Molecular Rotors in Living Cells

Published on: February 9, 2012

25.9K

Reentry as an Origin for Rotors.

A Rabinovitch1, I Aviram2, Y Biton2

  • 1Physics Department, Ben-Gurion University of the Negev, 84105, Beer-Sheva, Israel. avinoam@bgu.ac.il.

Bulletin of Mathematical Biology
|September 19, 2018
PubMed
Summary
This summary is machine-generated.

This study reveals how cardiac reentry can generate spiral waves, potentially causing heart fibrillation and brain epilepsy. Understanding these mechanisms may lead to new treatments for cardiac arrhythmias.

Keywords:
EpilepsyFibrillationReentryRotors

More Related Videos

How to Build a Vacuum Spring-transport Package for Spinning Rotor Gauges
09:26

How to Build a Vacuum Spring-transport Package for Spinning Rotor Gauges

Published on: April 7, 2016

9.6K
A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
06:23

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

Published on: September 22, 2020

6.1K

Related Experiment Videos

Last Updated: Feb 5, 2026

Fluorescence Lifetime Imaging of Molecular Rotors in Living Cells
09:45

Fluorescence Lifetime Imaging of Molecular Rotors in Living Cells

Published on: February 9, 2012

25.9K
How to Build a Vacuum Spring-transport Package for Spinning Rotor Gauges
09:26

How to Build a Vacuum Spring-transport Package for Spinning Rotor Gauges

Published on: April 7, 2016

9.6K
A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
06:23

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

Published on: September 22, 2020

6.1K

Area of Science:

  • * Computational biology
  • * Biophysics
  • * Cardiac electrophysiology

Background:

  • * Reentry is a proposed mechanism for cardiac arrhythmias like tachycardia and fibrillation.
  • * The precise mechanisms of spiral wave generation in reentry circuits remain incompletely understood.
  • * Potential implications extend to neurological disorders such as epilepsy.

Purpose of the Study:

  • * To elucidate the fundamental mechanisms of reentry.
  • * To investigate how reentry can lead to spiral wave formation.
  • * To explore the link between reentry phenomena and cardiac/neurological malfunctions.

Main Methods:

  • * A simplified computational model simulating a reentry circuit.
  • * Analysis of action potential propagation and spiral wave dynamics.
  • * Identification of distinct spiral generation mechanisms.

Main Results:

  • * Demonstrated two distinct mechanisms for spiral generation from a rotating action potential in a ring model.
  • * Identified spiral adhesion to the core, forming double-spiral patterns and generating new single spirals.
  • * Observed a second mechanism involving repeated figure-of-eight double spiral creation.

Conclusions:

  • * Provided a detailed mechanistic understanding of spiral generation via reentry.
  • * Established the link between reentry, spiral dynamics, and cardiac/neurological pathologies.
  • * Suggested potential for novel therapeutic strategies, such as ablation, for conditions like heart fibrillation.