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Recent advances in understanding the role of FOXO3

Renae J Stefanetti1, Sarah Voisin2, Aaron Russell3

  • 1Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, UK.

F1000Research
|September 20, 2018
PubMed

Insights

Forkhead box O3 (FOXO3) is a gene linked to longevity. Research highlights its role in skeletal muscle protein turnover, the genetic basis of aging, and microRNA regulation of the cell cycle.

Area of Science:

  • Molecular Biology
  • Genetics
  • Aging Research

Background:

  • Forkhead box O3 (FOXO3) is a transcription factor regulating vital cellular processes.
  • FOXO3 is consistently associated with longevity in various models.
  • Its role extends beyond insulin regulation to metabolism, cell survival, and death.

Purpose of the Study:

  • To review recent research on FOXO3's function in skeletal muscle protein turnover.
  • To explore the genetic underpinnings of longevity related to FOXO3.
  • To examine microRNA regulation of FOXO3 and its effect on the cell cycle.

Main Methods:

  • Literature review of recent studies on FOXO3.
  • Analysis of research on gene regulation and longevity.
  • Exploration of microRNA interactions with FOXO3.

Main Results:

  • FOXO3 plays a critical role in regulating protein turnover within skeletal muscle.
  • Genetic factors involving FOXO3 are significantly linked to lifespan.
  • MicroRNAs modulate FOXO3 activity, influencing cell cycle progression.

Conclusions:

  • FOXO3 is a key determinant of skeletal muscle health and longevity.
  • Understanding FOXO3's genetic regulation is crucial for aging research.
  • MicroRNA-mediated control of FOXO3 impacts cellular processes relevant to aging and disease.
Keywords:
FOXO3longevitymicroRNAprotein turnoverskeletal muscletranscription factor

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