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Biaxial Mechanical Characterizations of Atrioventricular Heart Valves
Published on: April 9, 2019
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A Non-Invasive Material Characterization Framework for Bioprosthetic Heart Valves
Mostafa Abbasi1, Mohammed S Barakat1, Danny Dvir2
1The DU Cardiovascular Biomechanics Laboratory, Department of Mechanical and Materials Engineering, University of Denver, Denver, CO, USA.
Annals of Biomedical Engineering
|September 20, 2018
Summary
Accurate mechanical properties of bioprosthetic heart valve leaflets are crucial for reliable computational models. This study presents a non-invasive framework to characterize these properties, revealing potential differences in long-term durability among transcatheter aortic valve models.
Area of Science:
- Biomedical Engineering
- Computational Mechanics
- Materials Science
Background:
- Computational modeling and simulation are increasingly vital in designing bioprosthetic heart valves.
- Accurate characterization of biological soft tissue mechanical properties is essential for reliable computational models.
Purpose of the Study:
- To present a non-invasive material characterization framework for determining the mechanical properties of soft tissue used in bioprosthetic heart valves.
- To characterize and compare the mechanical properties of leaflets from two transcatheter aortic valves (TAVs) and one surgical bioprosthesis.
Main Methods:
- Integrated experimental methods: digital image correlation and hemodynamic testing in a pulse duplicator system.
- Numerical methods: finite element modeling and optimization.
- Characterization of three-dimensional anisotropic mechanical properties of valve leaflets.
Main Results:
- Highest stress values observed at peak systole across all three bioprostheses.
- Peak maximum in-plane principal stress during diastole: 0.98 MPa (PERIMOUNT Magna), 0.96 MPa (CoreValve), and 2.95 MPa (SAPIEN 3).
- Leaflet stress distributions suggest potential differences in long-term durability among TAV models.
Conclusions:
- The developed framework enables non-invasive characterization of bioprosthetic heart valve leaflet mechanics.
- Significant variations in stress distribution exist between different TAV models, impacting predicted long-term durability.
- Further investigation into stress-durability relationships is warranted for TAV design optimization.
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