Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Degradative enzyme systems in cartilage.

M G Ehrlich, A L Armstrong, B V Treadwell

    Clinical Orthopaedics and Related Research
    |December 1, 1986
    PubMed
    Summary

    Osteoarthritis pathogenesis involves increased cartilage-degrading enzymes, potentially triggered by a messenger protein. Inhibiting these enzymes may offer a novel treatment for osteoarthritis.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Functional and oncological outcome after surgical resection of the scapula and clavicle for primary chondrosarcoma.

    Musculoskeletal surgery·2016
    Same author

    Liposarcoma: a soft tissue tumor with many presentations.

    Musculoskeletal surgery·2014
    Same author

    Schwannoma: a rare benign tumor of soft tissues.

    Musculoskeletal surgery·2014
    Same author

    Osteoid osteoma: an unusual presentation as a rib lesion: a case report.

    Orthopedics·2014
    Same author

    Pleomorphic spindle cell sarcoma (PSCS) formerly known as malignant fibrous histiocytoma (MFH): a complex malignant soft-tissue tumor.

    Musculoskeletal surgery·2012
    Same author

    Reconstruction for instability of the sternoclavicular joint using the tendon of the sternocleidomastoid muscle.

    The Journal of bone and joint surgery. British volume·2008

    Area of Science:

    • Biochemistry
    • Pathology
    • Rheumatology

    Background:

    • Osteoarthritis (OA) pathogenesis is complex, with various initiating factors.
    • A common final pathway is proposed, involving cartilage degradation.
    • Cartilage-degrading enzymes play a crucial role in OA progression.

    Purpose of the Study:

    • To identify a common pathway in osteoarthritis pathogenesis.
    • To investigate the role of degradative enzymes in OA.
    • To explore potential therapeutic targets for OA treatment.

    Main Methods:

    • Analysis of enzyme activity in relation to OA severity.
    • Investigation of cartilage-derived enzymes.
    • Studies in an animal model of osteoarthritis.

    Main Results:

    • A common pathway in OA pathogenesis involves increased neutral pH-active proteoglycan- and collagen-degrading enzymes.
    • Enzyme activity correlates with arthritis severity.
    • A synovial messenger protein, similar to interleukin-1, may trigger increased enzyme activity.

    Conclusions:

    • Osteoarthritis shares a final common pathway irrespective of the initial cause.
    • Increased degradative enzyme activity is a key feature of end-stage OA.
    • Enzyme inhibition presents a potential therapeutic strategy for osteoarthritis.

    Related Experiment Videos